Linked Life Data

10510186

Source:http://linkedlifedata.com/resource/pubmed/id/10510186

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1999-11-24
pubmed:abstractText
Whereas it has been shown that early monocular enucleations produce a reduction in the uncrossed pathway from the surviving eye in rats and ferrets, similar evidence for binocular interactions in the development of the uncrossed component in mice is currently open to question. Using retrograde tracing, we have investigated the time course of changes in the uncrossed retinofugal pathway immediately after the early prenatal monocular enucleation in mouse embryos. Removal of one eye from C57 pigmented mice at embryonic day (E) 13 does not cause a reduction of the earliest uncrossed component from the central retina examined 1 day later at E14. However, a substantial reduction of the uncrossed pathway is seen at E15, the time when the major uncrossed projection first arises from the ventral temporal retina. This reduction is greater in E16 one-eyed embryos, indicating that most retinal axons from the ventral temporal retina rely on a binocular interaction for their turning at the chiasm. Further, early removal of one eye at E13 does not produce any obvious changes in the cytoarchitecture of RC-2-immunopositive radial glia at the chiasm, nor of the stage-specific antigen-1 (SSEA-1) -expressing neurons. This lack of changes in the cellular organization at the chiasm indicates that the reduction of the uncrossed pathway is probably produced by an elimination of binocular fibre interactions at the chiasm, rather than through a degenerative change of cellular elements at the chiasm as a consequence of the eye removal procedure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0953-816X
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3225-35
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
The effects of early prenatal monocular enucleation on the routing of uncrossed retinofugal axons and the cellular environment at the chiasm of mouse embryos.
pubmed:affiliation
Department of Anatomy, Chinese University of Hong Kong, Shatin, NT, PR China. b108714@mailserv.cuhk.edu.hk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't