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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1999-11-4
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pubmed:abstractText |
Death receptor-mediated apoptosis can be modulated by several antiapoptotic proteins, such as the FLICE (FADD [Fas-associated death domain]-like IL-1beta-converting enzyme)-inhibitory proteins (FLIPs). The FLIP family includes both cellular and viral members. The Kaposi's sarcoma-associated herpesvirus protein (KSHV)-FLIP is expressed by human herpesvirus 8 (HHV-8), which is associated with malignancies such as Kaposi's sarcoma and certain lymphomas. In this paper, we demonstrate that KSHV-FLIP protects cells from Fas-mediated apoptosis by inhibiting caspase activation and permits clonal growth in the presence of death stimuli in vitro. Furthermore, we show that KSHV-FLIP can act as a tumor progression factor by promoting tumor establishment and growth in vivo. When injected into immunocompetent recipient mouse strains, murine B lymphoma cells (A20) transduced with KSHV-FLIP rapidly develop into aggressive tumors showing a high rate of survival and growth. The tumor-progressive activity of KSHV-FLIP is mediated by prevention of death receptor-induced apoptosis triggered by conventional T cells. Consequently, inhibitors of death receptor signaling can be regarded as a new class of tumor progression factors, and HHV-8-associated tumors may represent naturally occurring examples of the tumorigenic effect of such inhibitors.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-10510078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-2631796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-310843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-7009746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-7596430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-7878464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-8612236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-9039780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-9087414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-9108079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-9217161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-9256286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-9382834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-9632731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-9695946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-9721089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-9721091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-9735050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-9743343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-9785672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510092-9802983
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CASP8 and FADD-Like Apoptosis...,
http://linkedlifedata.com/resource/pubmed/chemical/CASP8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CASP9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CFLAR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Casp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Casp8 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Casp9 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 8,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Cflar protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
190
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1025-32
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10510092-Animals,
pubmed-meshheading:10510092-Antigens, CD95,
pubmed-meshheading:10510092-Apoptosis,
pubmed-meshheading:10510092-CASP8 and FADD-Like Apoptosis Regulating Protein,
pubmed-meshheading:10510092-Carrier Proteins,
pubmed-meshheading:10510092-Caspase 3,
pubmed-meshheading:10510092-Caspase 8,
pubmed-meshheading:10510092-Caspase 9,
pubmed-meshheading:10510092-Caspases,
pubmed-meshheading:10510092-Crosses, Genetic,
pubmed-meshheading:10510092-Disease Progression,
pubmed-meshheading:10510092-Herpesvirus 8, Human,
pubmed-meshheading:10510092-Humans,
pubmed-meshheading:10510092-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:10510092-Lymphoma, B-Cell,
pubmed-meshheading:10510092-Lymphoma, T-Cell,
pubmed-meshheading:10510092-Mice,
pubmed-meshheading:10510092-Mice, Inbred BALB C,
pubmed-meshheading:10510092-Mice, Inbred C57BL,
pubmed-meshheading:10510092-Signal Transduction,
pubmed-meshheading:10510092-T-Lymphocytes,
pubmed-meshheading:10510092-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
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pubmed:affiliation |
Department of Immunology, Wenner-Gren Institute, University of Stockholm, S-10691 Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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