Source:http://linkedlifedata.com/resource/pubmed/id/10509800
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
1999-11-19
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pubmed:abstractText |
The juvenoid, methyl farnesoate (MF), is synthesized in the mandibular organs (MOs) of crustaceans, under the control of mandibular organ-inhibiting hormone (MO-IH). Using an in vitro assay to measure synthesis of MF by MOs, the effect of a variety of agents that affect signal transduction pathways was investigated. Of the compounds tested, only agents which affect cAMP (forskolin and 8-bromoadenosine cyclic-3',5'-monophosphate) levels were found to mimic the inhibitory action of MO-IH on MF synthesis. To further support these findings, the effect of MO-IH-1 on production of cAMP was investigated. The results demonstrated that MO-IH stimulated a dose-dependent increase in cAMP levels. Furthermore, a maximal 2-fold increase in cAMP was detected after a 5-min exposure of MO membranes to 100 nM MO-IH-1, falling to basal levels thereafter. The results presented strongly support a role for cAMP in the signal transduction mechanism of MO-IH that leads to inhibition of MF synthesis in MOs.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-Bromo Cyclic Adenosine...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Forskolin,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/mandibular organ-inhibiting...,
http://linkedlifedata.com/resource/pubmed/chemical/methyl farnesoate
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0303-7207
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
154
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
55-62
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10509800-8-Bromo Cyclic Adenosine Monophosphate,
pubmed-meshheading:10509800-Animals,
pubmed-meshheading:10509800-Brachyura,
pubmed-meshheading:10509800-Cyclic AMP,
pubmed-meshheading:10509800-Fatty Acids, Unsaturated,
pubmed-meshheading:10509800-Female,
pubmed-meshheading:10509800-Forskolin,
pubmed-meshheading:10509800-Mandible,
pubmed-meshheading:10509800-Neuropeptides,
pubmed-meshheading:10509800-Second Messenger Systems,
pubmed-meshheading:10509800-Signal Transduction
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pubmed:year |
1999
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pubmed:articleTitle |
Involvement of adenosine cyclic-3',5'-monophosphate in the signal transduction pathway of mandibular organ-inhibiting hormone of the edible crab, Cancer pagurus.
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pubmed:affiliation |
School of Biological Sciences, University of Liverpool, UK. geoffw@liv.ac.uk
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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