Source:http://linkedlifedata.com/resource/pubmed/id/10508812
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1999-11-16
|
| pubmed:abstractText |
This longitudinal study (1992-1994) was performed to determine the relation between accidental chlorine exposure and changes in lung function and airway responsiveness in 239 workers in a metal production plant. These workers had taken part in a cross-sectional survey in 1992. In both the initial and the follow-up surveys, history of exposure to chlorine ("puffs"), accidental chlorine inhalation reported to the first-aid unit (gassing incidents), and of chronic symptoms were documented; spirometry and methacholine challenge tests were performed. At follow-up, 211 workers (88.3%) were seen. In workers with 20 pack-years or more of cigarette smoking, the fall in FEV(1) was associated with having had a gassing incident during the follow-up period; the fall in FEV(1)/FVC (%) was predicted by the number of puffs causing mild symptoms between the two assessments. An increase in airway responsiveness (PC(20) decrease > 1.5-fold) was present in 19 workers; it was associated with accidents reported to the first-aid unit during the previous 2 yr (OR: 5.9, 95% CI: 1.1 to 32.3). These findings suggest: (1) an effect on airway function related to the estimated number of puffs with mild symptoms and gassing incidents, mostly among smokers; (2) a detectable increase in airway responsiveness associated with gassing incidents.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
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| pubmed:issn |
1073-449X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
160
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1232-7
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10508812-Accidents, Occupational,
pubmed-meshheading:10508812-Bronchial Hyperreactivity,
pubmed-meshheading:10508812-Bronchial Provocation Tests,
pubmed-meshheading:10508812-Bronchoconstrictor Agents,
pubmed-meshheading:10508812-Chlorine,
pubmed-meshheading:10508812-Female,
pubmed-meshheading:10508812-Follow-Up Studies,
pubmed-meshheading:10508812-Forced Expiratory Volume,
pubmed-meshheading:10508812-Humans,
pubmed-meshheading:10508812-Inhalation Exposure,
pubmed-meshheading:10508812-Longitudinal Studies,
pubmed-meshheading:10508812-Male,
pubmed-meshheading:10508812-Metallurgy,
pubmed-meshheading:10508812-Methacholine Chloride,
pubmed-meshheading:10508812-Middle Aged,
pubmed-meshheading:10508812-Occupational Exposure,
pubmed-meshheading:10508812-Respiration Disorders,
pubmed-meshheading:10508812-Smoking,
pubmed-meshheading:10508812-Spirometry,
pubmed-meshheading:10508812-Vital Capacity
|
| pubmed:year |
1999
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| pubmed:articleTitle |
Longitudinal assessment of airway caliber and responsiveness in workers exposed to chlorine.
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| pubmed:affiliation |
Department of Chest Medicine, Hôpital du Sacré-Coeur, University of Montreal, Quebec, Canada. D-Gautrin@crhsc.umontreal.ca
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|