Linked Life Data

10508692

Source:http://linkedlifedata.com/resource/pubmed/id/10508692

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1999-11-23
pubmed:abstractText
Recent research in Drosophila and in mammals has generated fascinating new models for how circadian clocks in these organisms are reset by light and how these clocks, in turn, direct circadian outputs. Though light perception by the central clock is ocular in mammals, it probably proceeds via a mechanism separate from traditional visual transduction. In Drosophila, one mechanism is non-ocular and is in fact present in many different tissues. In both organisms, the cryptochrome family of photoreceptor-like molecules plays a role in the circadian clock, though their function is incompletely understood. Moreover, although a master clock resides in the brain, a functional clock appears to reside in most cells of the body. In these tissues, at least some output genes are controlled at the transcriptional level directly by clock proteins; others appear to be regulated by cascades of circadian transcription factors. Taken together, these observations are reshaping thinking about inputs and outputs of metazoan circadian clocks.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0959-437X
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
588-94
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
The ins and outs of circadian timekeeping.
pubmed:affiliation
Départment de Biologie Moleculaire Université de Genéve Sciences II 30 quai Ernest-Ansermet, 1211, Genéve 4, Switzerland. steven. brown@molbio.unige.ch.
pubmed:publicationType
Journal Article, Review