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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1999-11-30
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pubmed:abstractText |
TP53 gene plays a major role in the process of malignant transformation and tumour progression so that abnormalities such as point mutation or allelic loss of this gene are a common finding in different tumour types. Most of the mutations identified cover a conserved region of the gene, spanning from exon 4 to exon 9. The present report describes a novel polymorphism, 12 nucleotides downstream the splicing junction of exon/intron 9 identified in a cohort of 103 Italian healthy blood donors. The polymorphism results in the creation of a new restriction site for Ava I.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0890-8508
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1999 Academic Press.
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
393-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10508562-Blood Donors,
pubmed-meshheading:10508562-DNA Restriction Enzymes,
pubmed-meshheading:10508562-Exons,
pubmed-meshheading:10508562-Female,
pubmed-meshheading:10508562-Gene Frequency,
pubmed-meshheading:10508562-Genes, p53,
pubmed-meshheading:10508562-Humans,
pubmed-meshheading:10508562-Introns,
pubmed-meshheading:10508562-Italy,
pubmed-meshheading:10508562-Male,
pubmed-meshheading:10508562-Point Mutation,
pubmed-meshheading:10508562-Polymorphism, Genetic,
pubmed-meshheading:10508562-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:10508562-Polymorphism, Single-Stranded Conformational
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pubmed:year |
1999
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pubmed:articleTitle |
An Ava I polymorphism in the TP53 gene.
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pubmed:affiliation |
Il Department of Pathology, University of Milan School of Medicine, Via A di Rudinì 8, Milano, 20142, Italy.
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pubmed:publicationType |
Journal Article
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