Source:http://linkedlifedata.com/resource/pubmed/id/10508487
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1999-11-18
|
| pubmed:abstractText |
Using differential-display RT-PCR analysis between androgen-dependent LNCaP-FGC and androgen-independent LNCaP-LNO human prostate-cancer cells, we have identified a gene not previously described as being expressed in prostate. The gene is more highly expressed in androgen-independent than in androgen-dependent LNCaP prostate-cancer cells. Sequence analysis showed that the gene has already been cloned as a transcript present in embryonic brain, with unknown functions. Expression of the gene was found not to be restricted to the prostate, and not regulated by androgens in androgen-independent prostate-cancer cells. In concert with the cell-culture system, Northern-blot analysis of gene expression in vivo, using a panel of human prostate-cancer xenografts, demonstrated that the gene is more highly expressed in androgen-independent than in androgen-dependent prostate-cancer xenografts. The gene could be mapped on human chromosome 8q11. The 8q arm is known to be frequently amplified during prostate-cancer progression and harbors several proto-oncogenes potentially involved in cancer development. Since expression of the gene is positively correlated with prostate-cancer progression and its 8q11 chromosomal localization, we hypothesize that the gene may be involved in the development and progression of prostate cancer.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0020-7136
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 1999 Wiley-Liss, Inc.
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| pubmed:issnType |
Print
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| pubmed:day |
12
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| pubmed:volume |
83
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
506-11
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| pubmed:dateRevised |
2007-7-24
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| pubmed:meshHeading |
pubmed-meshheading:10508487-Animals,
pubmed-meshheading:10508487-Base Sequence,
pubmed-meshheading:10508487-Blotting, Northern,
pubmed-meshheading:10508487-Carcinoma,
pubmed-meshheading:10508487-Chromosome Mapping,
pubmed-meshheading:10508487-Chromosomes, Human, Pair 8,
pubmed-meshheading:10508487-Disease Progression,
pubmed-meshheading:10508487-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10508487-Genes, Neoplasm,
pubmed-meshheading:10508487-Humans,
pubmed-meshheading:10508487-Male,
pubmed-meshheading:10508487-Mice,
pubmed-meshheading:10508487-Mice, Nude,
pubmed-meshheading:10508487-Molecular Sequence Data,
pubmed-meshheading:10508487-Neoplasm Transplantation,
pubmed-meshheading:10508487-Neoplasms, Hormone-Dependent,
pubmed-meshheading:10508487-Prostatic Neoplasms,
pubmed-meshheading:10508487-RNA, Messenger,
pubmed-meshheading:10508487-Tumor Cells, Cultured
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Identification of a gene on human chromosome 8q11 that is differentially expressed during prostate-cancer progression.
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| pubmed:affiliation |
Department of Endocrinology and Reproduction, Erasmus University, Rotterdam, The Netherlands. chang@endov.fgg.eur.nl
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|