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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1979-4-25
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pubmed:abstractText |
The nature of the opsonic factors in nonimmune human serum for six blood culture isolates of Pseudomonas aeruginosa was investigated by measuring uptake of [3H] adenine-labeled bacteria by human PMNs. Normal human serum, C2- and C4-deficient sera, zymosan-treated serum, and immunoglobulin-deficient sera were used as opsonic sources. Heat inactivation of each of these serum sources markedly reduced its opsonic capacity for all Pseudomonas strains, suggesting that the serum C system was essential for opsonization. Five strains were opsonized in the absence of the classical C pathway; however, kinetic studies revealed that opsonization proceeded at a faster rate when the classical pathway was present. In spite of markedly reduced factor B and C3 levels, zymosan-treated serum retained significant opsonic activity for one of the strains tested. Four strains were poorly opsonized by immunoglobulin-deficient serum, and C activation by these strains appeared to depend upon the presence of antibodies. Two strains, however, were effectively opsonized in a relative absence of antibodies. Thus, in the nonimmune state, phagocytosis of P. aeruginosa is mediated primarily via the C system, and antibodies appear to play a role in the opsonization of some but perhaps not all Pseudomonas strains.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-2143
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
883-94
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:105067-Complement Factor B,
pubmed-meshheading:105067-Complement Pathway, Alternative,
pubmed-meshheading:105067-Complement Pathway, Classical,
pubmed-meshheading:105067-Complement System Proteins,
pubmed-meshheading:105067-Hot Temperature,
pubmed-meshheading:105067-Humans,
pubmed-meshheading:105067-Immunoglobulins,
pubmed-meshheading:105067-Neutrophils,
pubmed-meshheading:105067-Opsonin Proteins,
pubmed-meshheading:105067-Phagocytosis,
pubmed-meshheading:105067-Pseudomonas aeruginosa
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pubmed:year |
1978
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pubmed:articleTitle |
Complement-mediated phagocytosis of Pseudomonas aeruginosa.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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