Source:http://linkedlifedata.com/resource/pubmed/id/10503995
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1999-10-29
|
| pubmed:abstractText |
Nitric oxide (NO) has divergent actions under physiological and pathological conditions. NO is rapidly decomposed to nitrite (NO2-) and nitrate (NO3-). Since these metabolites are stable, they are good indices of NO production under various conditions. In the present study, we measured NO2- and NO3- concentrations in the urine collected from 62 hospital controls and 504 healthy subjects by means of a new HPLC system combined with Griess reaction. NOx was the sum of NO2- and NO3-. There was no considerable inter-day variation in urinary NO metabolite levels, and there was close correlation between NO2-, NO3- and NOx values in spot urine obtained in the early morning and those in 24-h stored urine in hospital controls. Urinary NO metabolite levels, which were corrected by creatinine (Cr) excretion and expressed on a logarithmic scale, showed normal distribution and were independent of sex and age in healthy subjects. The normal ranges of urinary NO2-, NO3- and NOx levels were estimated as 17-72 micromol/g Cr, 1,023-2,818 pmol/g Cr, and 1,071-2,951 micromol/g Cr, respectively. We also found that urinary NO metabolite levels were lower than normal range in patients with various diseases.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0918-8959
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
46
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
421-8
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10503995-Adolescent,
pubmed-meshheading:10503995-Adult,
pubmed-meshheading:10503995-Aged,
pubmed-meshheading:10503995-Aged, 80 and over,
pubmed-meshheading:10503995-Aging,
pubmed-meshheading:10503995-Arthritis, Rheumatoid,
pubmed-meshheading:10503995-Chromatography, High Pressure Liquid,
pubmed-meshheading:10503995-Diabetes Mellitus, Type 2,
pubmed-meshheading:10503995-Drug Stability,
pubmed-meshheading:10503995-Female,
pubmed-meshheading:10503995-Humans,
pubmed-meshheading:10503995-Hypothalamic Diseases,
pubmed-meshheading:10503995-Kidney Diseases,
pubmed-meshheading:10503995-Male,
pubmed-meshheading:10503995-Middle Aged,
pubmed-meshheading:10503995-Nitrates,
pubmed-meshheading:10503995-Nitric Oxide,
pubmed-meshheading:10503995-Nitrites,
pubmed-meshheading:10503995-Reference Values,
pubmed-meshheading:10503995-Sodium Azide
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Analysis of urinary nitric oxide metabolites in healthy subjects.
|
| pubmed:affiliation |
Department of Medicine, Shimane Medical University, Izumo, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|