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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
5
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pubmed:dateCreated |
1999-11-12
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pubmed:abstractText |
The methoxymorpholinyl doxorubicin analogue PNU 152243 was brought into clinical studies because of preclinical observations of its non-cross-resistance in mdr tumor cells, dose-limiting neutropenia, lack of cardiotoxicity, and antitumor activity after oral administration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0344-5704
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pubmed:author |
pubmed-author:BauerJJ,
pubmed-author:CavalliFF,
pubmed-author:D'IncalciMM,
pubmed-author:DomenigoniLL,
pubmed-author:GhielminiMM,
pubmed-author:NaegeleHH,
pubmed-author:PacciariniM AMA,
pubmed-author:RossiSS,
pubmed-author:SessaCC,
pubmed-author:ZucchettiMM,
pubmed-author:de JongJJ
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pubmed:issnType |
Print
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pubmed:volume |
44
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
403-10
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10501914-Administration, Oral,
pubmed-meshheading:10501914-Adolescent,
pubmed-meshheading:10501914-Adult,
pubmed-meshheading:10501914-Aged,
pubmed-meshheading:10501914-Antineoplastic Agents,
pubmed-meshheading:10501914-Area Under Curve,
pubmed-meshheading:10501914-Colonic Neoplasms,
pubmed-meshheading:10501914-Doxorubicin,
pubmed-meshheading:10501914-Female,
pubmed-meshheading:10501914-Half-Life,
pubmed-meshheading:10501914-Humans,
pubmed-meshheading:10501914-Leukocyte Count,
pubmed-meshheading:10501914-Male,
pubmed-meshheading:10501914-Middle Aged,
pubmed-meshheading:10501914-Neoplasms,
pubmed-meshheading:10501914-Neutrophils,
pubmed-meshheading:10501914-Pancreatic Neoplasms
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pubmed:year |
1999
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pubmed:articleTitle |
Phase I clinical and pharmacological study of oral methoxymorpholinyl doxorubicin (PNU 152243).
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pubmed:affiliation |
Istituto Oncologico della Svizzera Italiana, Division of Oncology, Ospedale San Giovanni, 6500 Bellinzona, Switzerland. csessa@ticino.com
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Clinical Trial, Phase I
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