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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1999-11-15
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pubmed:abstractText |
We evaluated the effects of chemical lesions on hindpaw inflammation-induced Fos protein expression in spinoparabrachial neurons that were retrogradely labeled by Fluoro-Gold. The descending serotoninergic and noradrenergic pathways were destroyed by the selective neurotoxins, 5,7-DHT and DSP-4, respectively. After 5,7-DHT treatment there was a significant increase in double-labeled neurons only in the lateral reticulated neck of the dorsal horn 24h after inflammation compared with vehicle-injected controls. In contrast, the DSP-4 treatment resulted in a more robust increase in double-labeled neurons in the ipsilateral superficial dorsal horn than in the neck of the dorsal horn. These results indicate that after inflammation the enhanced modulation from descending serotoninergic and noradrenergic pathways targets supraspinally projecting neurons to dampen increased ascending nociceptive input. Further, these pathways differentially suppress the responses of spinoparabrachial neurons in the deep and superficial dorsal horn.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-hydroxy-4,4'-diamidinostilbene...,
http://linkedlifedata.com/resource/pubmed/chemical/5,7-Dihydroxytryptamine,
http://linkedlifedata.com/resource/pubmed/chemical/Benzylamines,
http://linkedlifedata.com/resource/pubmed/chemical/DSP 4,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorescent Dyes,
http://linkedlifedata.com/resource/pubmed/chemical/Freund's Adjuvant,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fos,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Stilbamidines
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1757-61
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10501570-5,7-Dihydroxytryptamine,
pubmed-meshheading:10501570-Animals,
pubmed-meshheading:10501570-Benzylamines,
pubmed-meshheading:10501570-Fluorescent Dyes,
pubmed-meshheading:10501570-Freund's Adjuvant,
pubmed-meshheading:10501570-Hindlimb,
pubmed-meshheading:10501570-Image Processing, Computer-Assisted,
pubmed-meshheading:10501570-Immunohistochemistry,
pubmed-meshheading:10501570-Inflammation,
pubmed-meshheading:10501570-Neural Pathways,
pubmed-meshheading:10501570-Neurons,
pubmed-meshheading:10501570-Nociceptors,
pubmed-meshheading:10501570-Norepinephrine,
pubmed-meshheading:10501570-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:10501570-Rats,
pubmed-meshheading:10501570-Rats, Sprague-Dawley,
pubmed-meshheading:10501570-Serotonin,
pubmed-meshheading:10501570-Serotonin Agents,
pubmed-meshheading:10501570-Spinal Cord,
pubmed-meshheading:10501570-Stilbamidines
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pubmed:year |
1999
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pubmed:articleTitle |
Laminar-selective noradrenergic and serotoninergic modulation includes spinoparabrachial cells after inflammation.
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pubmed:affiliation |
Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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