Source:http://linkedlifedata.com/resource/pubmed/id/10501485
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1999-10-7
|
| pubmed:abstractText |
Since its characterization in 1995, there has been increasing interest in the significance of GB virus B (GBV-B) due to its close phylogenetic relationship to hepatitis C virus (HCV). The genome of GBV-B is similar in length and organization to that of HCV and the two viruses share sequence similarity in their 5' untranslated regions (5'UTR). A secondary structure model of the GBV-B 5'UTR has been proposed by comparative sequence analysis with HCV. The highly conserved secondary structure, present in HCV and the pestiviruses, is also present in the 5'UTR of GBV-B. Translation of the HCV polyprotein initiates via an internal ribosome entry site (IRES) and it is proposed that the GBV-B UTR may function in a similar manner. Dicistronic reporter constructs were made to investigate the function of the GBV-B 5'UTR. Mutational analysis and in vitro translation experiments demonstrate that GBV-B initiates translation via an IRES.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0022-1317
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
80 ( Pt 9)
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2337-41
|
| pubmed:dateRevised |
2002-11-1
|
| pubmed:meshHeading | |
| pubmed:year |
1999
|
| pubmed:articleTitle |
The 5' untranslated region of GB virus B shows functional similarity to the internal ribosome entry site of hepatitis C virus.
|
| pubmed:affiliation |
Virology, GlaxoWellcome Medicines Research Centre, Stevenage, UK. kgg29888@glaxowellcome.co.uk
|
| pubmed:publicationType |
Journal Article
|