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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1999-10-20
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pubmed:abstractText |
Beta2-Glycoprotein I (beta2GPI) exon 7 polymorphism leads to a valine leucine amino acid exchange at position 247 in domain 5 of beta2GPI, between the phospholipid binding site and the cryptic site of the epitopes for anti-beta2GPI antibodies. Therefore, position 247 polymorphism may affect the conformational change of beta2GPI and the exposure of the epitopes for anticardiolipin antibodies (aCL) (= anti-beta2GPI antibodies). In this study we analysed the genetic polymorphism of beta2GPI in a British cohort of well-defined antiphospholipid syndrome (APS) patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1462-0324
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
721-3
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pubmed:dateRevised |
2007-9-6
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pubmed:meshHeading |
pubmed-meshheading:10501418-Adolescent,
pubmed-meshheading:10501418-Adult,
pubmed-meshheading:10501418-Aged,
pubmed-meshheading:10501418-Amino Acid Substitution,
pubmed-meshheading:10501418-Antiphospholipid Syndrome,
pubmed-meshheading:10501418-Autoantibodies,
pubmed-meshheading:10501418-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:10501418-Female,
pubmed-meshheading:10501418-Glycoproteins,
pubmed-meshheading:10501418-Humans,
pubmed-meshheading:10501418-Male,
pubmed-meshheading:10501418-Middle Aged,
pubmed-meshheading:10501418-Polymerase Chain Reaction,
pubmed-meshheading:10501418-Polymorphism, Genetic,
pubmed-meshheading:10501418-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:10501418-beta 2-Glycoprotein I
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pubmed:year |
1999
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pubmed:articleTitle |
Correlation between beta2-glycoprotein I valine/leucine247 polymorphism and anti-beta2-glycoprotein I antibodies in patients with primary antiphospholipid syndrome.
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pubmed:affiliation |
Department of Medicine II, Hokkaido University School of Medicine, Sapporo, Japan.
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pubmed:publicationType |
Journal Article
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