| pubmed-article:10499925 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10499925 | lifeskim:mentions | umls-concept:C0004364 | lld:lifeskim |
| pubmed-article:10499925 | lifeskim:mentions | umls-concept:C0079784 | lld:lifeskim |
| pubmed-article:10499925 | lifeskim:mentions | umls-concept:C0018183 | lld:lifeskim |
| pubmed-article:10499925 | lifeskim:mentions | umls-concept:C0034050 | lld:lifeskim |
| pubmed-article:10499925 | lifeskim:mentions | umls-concept:C0475463 | lld:lifeskim |
| pubmed-article:10499925 | lifeskim:mentions | umls-concept:C0332240 | lld:lifeskim |
| pubmed-article:10499925 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10499925 | pubmed:dateCreated | 1999-10-19 | lld:pubmed |
| pubmed-article:10499925 | pubmed:abstractText | Idiopathic pulmonary alveolar proteinosis (I-PAP) is a rare disease of unknown etiology in which the alveoli fill with lipoproteinaceous material. We report here that I-PAP is an autoimmune disease with neutralizing antibody of immunoglobulin G isotype against granulocyte/macrophage colony-stimulating factor (GM-CSF). The antibody was found to be present in all specimens of bronchoalveolar lavage fluid obtained from 11 I-PAP patients but not in samples from 2 secondary PAP patients, 53 normal subjects, and 14 patients with other lung diseases. It specifically bound GM-CSF and neutralized bioactivity of the cytokine in vitro. The antibody was also found in sera from all I-PAP patients examined but not in sera from a secondary PAP patient or normal subjects, indicating that it exists systemically in I-PAP patients. As lack of GM-CSF signaling causes PAP in congenital cases and PAP-like disease in murine models, our findings strongly suggest that neutralization of GM-CSF bioactivity by the antibody causes dysfunction of alveolar macrophages, which results in reduced surfactant clearance. | lld:pubmed |
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| pubmed-article:10499925 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10499925 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10499925 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10499925 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10499925 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10499925 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:10499925 | pubmed:author | pubmed-author:YamadaYY | lld:pubmed |
| pubmed-article:10499925 | pubmed:author | pubmed-author:TanakaNN | lld:pubmed |
| pubmed-article:10499925 | pubmed:author | pubmed-author:KanegasakiSS | lld:pubmed |
| pubmed-article:10499925 | pubmed:author | pubmed-author:KitamuraTT | lld:pubmed |
| pubmed-article:10499925 | pubmed:author | pubmed-author:WatanabeJJ | lld:pubmed |
| pubmed-article:10499925 | pubmed:author | pubmed-author:NakataKK | lld:pubmed |
| pubmed-article:10499925 | pubmed:author | pubmed-author:Uchida | lld:pubmed |
| pubmed-article:10499925 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10499925 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:10499925 | pubmed:volume | 190 | lld:pubmed |
| pubmed-article:10499925 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10499925 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10499925 | pubmed:pagination | 875-80 | lld:pubmed |
| pubmed-article:10499925 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10499925 | pubmed:meshHeading | pubmed-meshheading:10499925... | lld:pubmed |
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| pubmed-article:10499925 | pubmed:meshHeading | pubmed-meshheading:10499925... | lld:pubmed |
| pubmed-article:10499925 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10499925 | pubmed:articleTitle | Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor. | lld:pubmed |
| pubmed-article:10499925 | pubmed:affiliation | The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan. | lld:pubmed |
| pubmed-article:10499925 | pubmed:publicationType | Journal Article | lld:pubmed |
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