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rdf:type |
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lifeskim:mentions |
umls-concept:C0003261,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0021017,
umls-concept:C0033268,
umls-concept:C0185117,
umls-concept:C0331432,
umls-concept:C0332120,
umls-concept:C0337112,
umls-concept:C0443199,
umls-concept:C0851285,
umls-concept:C1524075,
umls-concept:C1998793,
umls-concept:C2911684
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pubmed:issue |
9
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pubmed:dateCreated |
1999-10-8
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|
pubmed:abstractText |
A survey of the work with Ig response to allergens carried out previously reveals an allergen-specific response both by IgE and all of IgG subclasses. Response of non-sensitive people is characterized by the appearance of a variety of the IgG subclasses. We have reexamined ragweed and Amb a 1 specific Ig response in 54 nonsensitive and 147 atopic or atopic-allergic people using a new inverse sandwich immunoassay allowing discrimination based on antibody affinity. We show that non-sensitive people present no, 0 out of 54, Ig response with affinities higher than Ka 10(7) M(-1). The subpopulation of 66 atopics who never have experienced desensitization responds vigorously and solely (56 out of 66) with genes of the sequence gamma2-alpha2. Only ten showed an additional weak response from gamma1-alpha1. This suggests a possible association between the atopic state and selective activation of part of the gene sequence.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0161-5890
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
587-98
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10499812-Allergens,
pubmed-meshheading:10499812-Antibody Specificity,
pubmed-meshheading:10499812-Antigens, Plant,
pubmed-meshheading:10499812-Asteraceae,
pubmed-meshheading:10499812-Asthma,
pubmed-meshheading:10499812-Cross Reactions,
pubmed-meshheading:10499812-Gene Expression Regulation,
pubmed-meshheading:10499812-Genes, Immunoglobulin,
pubmed-meshheading:10499812-Humans,
pubmed-meshheading:10499812-Hypersensitivity,
pubmed-meshheading:10499812-Hypersensitivity, Immediate,
pubmed-meshheading:10499812-Immunoassay,
pubmed-meshheading:10499812-Immunoglobulin E,
pubmed-meshheading:10499812-Immunoglobulin G,
pubmed-meshheading:10499812-Immunoglobulin Heavy Chains,
pubmed-meshheading:10499812-Immunoglobulin Isotypes,
pubmed-meshheading:10499812-Immunotherapy,
pubmed-meshheading:10499812-Plant Proteins,
pubmed-meshheading:10499812-Pollen,
pubmed-meshheading:10499812-Rhinitis,
pubmed-meshheading:10499812-Skin Tests
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pubmed:year |
1999
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pubmed:articleTitle |
Expression of IgH chain genes in antibody response to ragweed and purified Amb a 1: evidence for differential regulation of isotype production.
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pubmed:affiliation |
The Asthma and Allergy Center, Department of Medicine, University of Minnesota Medical School, Minneapolis, USA.
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pubmed:publicationType |
Journal Article
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