Linked Life Data

10498801

Source:http://linkedlifedata.com/resource/pubmed/id/10498801

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1999-11-5
pubmed:abstractText
The interaction of lysophospholipids with human oxy- and methemoglobin was studied. Anionic (acidic) lysophospholipids (lysophosphatidylserine, lysophosphatidylinositol, lysophosphatidylethanol, and lysophosphatidic acid) are potent effectors inducing the conversion of both forms of hemoglobin into hemichrome. Zwitterionic lysophospholipids (lysophosphatidylcholine, lysophosphatidylethanolamine, and lysosphingomyelin) did not influence oxyhemoglobin conversion, whereas methemoglobin conversion into hemichrome required much higher concentrations of these lysophospholipids compared to anionic lysophospholipids. Neutralization of negative charge on phosphate group of acidic lysophospholipids by Ca2+ was accompanied by partial or complete loss of their effector properties. The process of hemoglobin conversion to hemichrome is characterized by two isobestic points in the absorption spectra, indicating lack of stable intermediates. The present results are discussed in terms of the biological sense of the asymmetric distribution of phospholipids in the erythrocyte membrane.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-2979
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
867-74
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Conversion of hemoglobin to hemichrome by lysophospholipids.
pubmed:affiliation
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, 220141, Belarus. kisel@ns.iboch.ac.by
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't