Source:http://linkedlifedata.com/resource/pubmed/id/10498189
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
17
|
| pubmed:dateCreated |
1999-10-28
|
| pubmed:abstractText |
A series of 3,6-disubstituted acridine derivatives have been rationally designed as telomerase inhibitors. They have been designed on the basis that inhibition of telomerase occurs by stabilising G-quadruplex structures formed by the folding of telomeric DNA. The most potent inhibitors have IC50 values against telomerase of between 1.3 and 8 microM, comparable to their cytotoxicity in ovarian cancer cell lines.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
6
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2463-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10498189-Acridines,
pubmed-meshheading:10498189-Antineoplastic Agents,
pubmed-meshheading:10498189-Drug Screening Assays, Antitumor,
pubmed-meshheading:10498189-Enzyme Inhibitors,
pubmed-meshheading:10498189-Humans,
pubmed-meshheading:10498189-Telomerase,
pubmed-meshheading:10498189-Tumor Cells, Cultured
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Human telomerase inhibition by substituted acridine derivatives.
|
| pubmed:affiliation |
CRC Biomolecular Structure Unit, The Institute of Cancer Research, Sutton, Surrey, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|