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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-10-26
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pubmed:abstractText |
For almost 40 years, 5-fluorouracil (5-FU) has been the only useful drug with clinically meaningful activity in metastatic colorectal carcinoma. When the disease progresses or recurs despite bolus 5-FU treatment, the options are limited. Our study shows that 5-FU given by continuous infusion is a viable alternative. Fifty-three patients received continuous infusion 5-FU. The overall response was 9%. Median survival of the entire cohort was 5 months. Patients with partial response and stable disease had median survival duration of 8 and 9 months, respectively. A dose-response relationship was observed. The commonest toxicities were mucositis (34%) and palmar-plantar syndrome (24%). There was no central line-related complication. Continuous infusion 5-FU is an effective "second-line" treatment. Further work is needed to ascertain its role, in comparison with newer agents like irinotecan (CPT-11), and oxaliplatin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0304-4602
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
256-9
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10497678-Antimetabolites, Antineoplastic,
pubmed-meshheading:10497678-Carcinoma,
pubmed-meshheading:10497678-Catheterization, Central Venous,
pubmed-meshheading:10497678-Cohort Studies,
pubmed-meshheading:10497678-Colonic Neoplasms,
pubmed-meshheading:10497678-Diarrhea,
pubmed-meshheading:10497678-Disease Progression,
pubmed-meshheading:10497678-Dose-Response Relationship, Drug,
pubmed-meshheading:10497678-Female,
pubmed-meshheading:10497678-Fluorouracil,
pubmed-meshheading:10497678-Follow-Up Studies,
pubmed-meshheading:10497678-Foot Diseases,
pubmed-meshheading:10497678-Hand,
pubmed-meshheading:10497678-Humans,
pubmed-meshheading:10497678-Infusions, Intravenous,
pubmed-meshheading:10497678-Male,
pubmed-meshheading:10497678-Middle Aged,
pubmed-meshheading:10497678-Mucous Membrane,
pubmed-meshheading:10497678-Neoplasm Recurrence, Local,
pubmed-meshheading:10497678-Rectal Neoplasms,
pubmed-meshheading:10497678-Remission Induction,
pubmed-meshheading:10497678-Salvage Therapy,
pubmed-meshheading:10497678-Survival Rate,
pubmed-meshheading:10497678-Syndrome
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pubmed:year |
1999
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pubmed:articleTitle |
Continuous infusion 5-fluorouracil as salvage chemotherapy in patients with advanced colorectal cancer.
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pubmed:affiliation |
Department of Medical Oncology, Singapore General Hospital, Singapore.
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pubmed:publicationType |
Journal Article
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