Source:http://linkedlifedata.com/resource/pubmed/id/10497230
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
40
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| pubmed:dateCreated |
1999-11-2
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| pubmed:abstractText |
Long chain fatty acid transport is selectively up-regulated in adipocytes of Zucker fatty rats, diverting fatty acids from sites of oxidation toward storage in adipose tissue. To determine whether this is a general feature of obesity, we studied [(3)H]oleate uptake by adipocytes and hepatocytes from 1) homozygous male obese (ob), diabetic (db), fat (fat), and tubby (tub) mice and from 2) male Harlan Sprague-Dawley rats fed for 7 weeks a diet containing 55% of calories from fat. V(max) and K(m) were compared with controls of the appropriate background strain (C57BL/6J or C57BLKS) or diet (13% of calories from fat). V(max) for adipocyte fatty acid uptake was increased 5-6-fold in ob, db, fat, and tub mice versus controls (p < 0.001), whereas no differences were seen in the corresponding hepatocytes. Similar changes occurred in fat-fed rats. Of three membrane fatty acid transporters expressed in adipocytes, plasma membrane fatty acid-binding protein mRNA was increased 9-11-fold in ob and db, which lack a competent leptin/leptin receptor system, but was not increased in fat and tub, i.e. in strains with normal leptin signaling capability; fatty acid translocase mRNA was increased 2.2-6.5-fold in tub, ob, and fat adipocytes, but not in db adipocytes; and only marginal changes in fatty acid transport protein 1 mRNA were found in any of the mutant strains. Adipocyte fatty acid uptake is generally increased in murine obesity models, but up-regulation of individual transporters depends on the specific pathophysiology. Leptin may normally down-regulate expression of plasma membrane fatty acid binding protein.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0021-9258
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
274
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
28626-31
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:10497230-Adipocytes,
pubmed-meshheading:10497230-Animals,
pubmed-meshheading:10497230-Blotting, Northern,
pubmed-meshheading:10497230-Diet,
pubmed-meshheading:10497230-Dietary Fats, Unsaturated,
pubmed-meshheading:10497230-Leptin,
pubmed-meshheading:10497230-Liver,
pubmed-meshheading:10497230-Male,
pubmed-meshheading:10497230-Mice,
pubmed-meshheading:10497230-Mice, Inbred C57BL,
pubmed-meshheading:10497230-Mice, Mutant Strains,
pubmed-meshheading:10497230-Obesity,
pubmed-meshheading:10497230-Oleic Acid,
pubmed-meshheading:10497230-Rats,
pubmed-meshheading:10497230-Rats, Sprague-Dawley,
pubmed-meshheading:10497230-Species Specificity,
pubmed-meshheading:10497230-Up-Regulation,
pubmed-meshheading:10497230-Weight Gain
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| pubmed:year |
1999
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| pubmed:articleTitle |
Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents.
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| pubmed:affiliation |
Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA. paul_berk@smtplink.mssm.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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