Linked Life Data

10494870

Source:http://linkedlifedata.com/resource/pubmed/id/10494870

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1999-10-21
pubmed:abstractText
Whereas pancreatic islet cells are not neurons, they are endodermally-derived specialized excitable cells that display many properties of neurons. Multiple ion channels in the pancreatic beta-cell regulate electrical excitability. Our focus for the last several years has been on the delayed rectifier (Kv) K+ channels, in an effort to define the individual roles of specific Kv channel genes in the overall regulation of insulin secretion. The many Kv channel genes, represented by more than 40 mammalian isoforms (termed Kv1 to Kv8), give rise to overlapping functions, primarily regulating repolarization of the plasma membrane. Experiments involving inhibition of Kv channel function have shown the important role Kv channels play in regulating beta-cell calcium oscillations in response to glucose stimulation. From our recent studies, we have concluded that although detectable mRNA for Kv1 family members is present in islets, Kv1 family channels are unlikely to play a significant role in the beta-cell, and we are now focusing on the roles of Kv2 and Kv3 channels.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0018-5043
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
455-61
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Beta-cell ion channels: keys to endodermal excitability.
pubmed:affiliation
Department of Medicine, University of Chicago, IL 60637, USA. l-philipson@uchicago.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't