Linked Life Data

10494102

Source:http://linkedlifedata.com/resource/pubmed/id/10494102

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-4-18
pubmed:abstractText
Multipotent progenitor cells have been identified within periventricular generative zones of the developing and adult brain. To determine whether the environmental responsiveness of these cells changes during development, progenitor cells were cultured from embryonic, postnatal, and adult rat brain in the presence of either basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). Embryonic cells cultured as intact progenitor neurospheres proliferated more robustly in response to bFGF than to EGF, whereas proliferation of postnatal and adult progenitor cells was enhanced more by EGF than bFGF. Progenitor cells generated in the presence of either bFGF or EGF had the capacity to generate neurons, astrocytes, and oligodendrocytes at all developmental stages. Most embryonic and neonatal bFGF-generated cells differentiated predominantly into neurons, whereas late stage embryonic and neonatal EGF-generated progenitors largely remained in an undifferentiated state. However, later postnatal and adult progenitor species, irrespective of whether they were generated in the presence of bFGF or EGF, gave rise preferentially to astrocytes. Treatment with bone morphogenetic protein (BMP)2 or BMP7 enhanced astroglial differentiation and suppressed oligodendroglial differentiation of both EGF- and bFGF-generated progenitor species, suggesting that the effects of the BMPs are not dependent on EGF receptor activation. Thus, while central nervous system (CNS) progenitor cells retain multipotent capacity and responsiveness to the BMPs throughout development, they exhibit significant changes in other cellular response properties, perhaps reflecting differences in the requirements for specific generative versus regenerative events.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0360-4012
pubmed:author
pubmed:copyrightInfo
Copyright 1999 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
131-45
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:10494102-Animals, pubmed-meshheading:10494102-Astrocytes, pubmed-meshheading:10494102-Bone Morphogenetic Protein 2, pubmed-meshheading:10494102-Bone Morphogenetic Protein 7, pubmed-meshheading:10494102-Bone Morphogenetic Proteins, pubmed-meshheading:10494102-Brain, pubmed-meshheading:10494102-Cell Cycle, pubmed-meshheading:10494102-Cell Differentiation, pubmed-meshheading:10494102-Cells, Cultured, pubmed-meshheading:10494102-Epidermal Growth Factor, pubmed-meshheading:10494102-Female, pubmed-meshheading:10494102-Fibroblast Growth Factor 2, pubmed-meshheading:10494102-Humans, pubmed-meshheading:10494102-Male, pubmed-meshheading:10494102-Pregnancy, pubmed-meshheading:10494102-Rats, pubmed-meshheading:10494102-Rats, Sprague-Dawley, pubmed-meshheading:10494102-Stem Cells, pubmed-meshheading:10494102-Transforming Growth Factor beta
pubmed:year
1999
pubmed:articleTitle
Developmental changes in progenitor cell responsiveness to cytokines.
pubmed:affiliation
Departments of Neurology and Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA. gzhu@aecom.yu.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.