Linked Life Data

10494036

Source:http://linkedlifedata.com/resource/pubmed/id/10494036

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1999-10-8
pubmed:abstractText
The human immunodeficiency virus (HIV-1) has evolved into a viral quasispecies with a high replication capacity or fitness. Antiretroviral drugs potently inhibit replication of the wild-type virus, but HIV-1 responds by selection of drug-resistant variants. Here we review, in brief, the evolution of resistance to protease inhibitors that is characterized by severe fitness losses and an abundance of subsequent repair strategies. The possibility to restrict HIV-1 fitness is discussed in relation to the control of HIV-1 pathogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1021-7770
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
298-305
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:articleTitle
HIV-1 evolution under pressure of protease inhibitors: climbing the stairs of viral fitness.
pubmed:affiliation
Department of Human Retrovirology, Academic Medical Center, Amsterdam, The Netherlands. b.berkhout@amc.uva.nl
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't