Source:http://linkedlifedata.com/resource/pubmed/id/10493178
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2-3
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pubmed:dateCreated |
1999-12-14
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pubmed:abstractText |
The conventional paradigm to explain systemic lupus erythematosus (SLE) is that disease results from tissue deposition of pathogenic autoantibodies and immune complexes, secondary to activation of autoreactive B cells in the context of help from alphabeta T cells. Recent work in murine lupus has confirmed this notion and demonstrated that autoantigen-specific alphabeta T cells are absolutely required for full penetrance of disease, with such autoreactive alphabeta T cells, even in Fas-intact mice, likely arising from defects in peripheral tolerance. These studies have also revealed a network of regulation that also involves nonclassical pathogenic and downregulatory alphabeta and gammadelta T cells, suggesting that the lupus immune system involves more complex interactions than the conventional paradigm suggests.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0257-277X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
245-57
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10493178-Animals,
pubmed-meshheading:10493178-Autoantibodies,
pubmed-meshheading:10493178-Disease Models, Animal,
pubmed-meshheading:10493178-Humans,
pubmed-meshheading:10493178-Lupus Erythematosus, Systemic,
pubmed-meshheading:10493178-Mice,
pubmed-meshheading:10493178-T-Lymphocytes
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pubmed:year |
1999
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pubmed:articleTitle |
Autoreactive T cells in murine lupus: origins and roles in autoantibody production.
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pubmed:affiliation |
Department of Medicine, Yale University School of Medicine, New Haven, CT 06520-8031, USA. joseph.craft@yale.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
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