Linked Life Data

10491818

Source:http://linkedlifedata.com/resource/pubmed/id/10491818

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1999-12-10
pubmed:abstractText
The response of an intracranial saccular aneurysm to applied loads, whether blood pressure or endovascular intervention, depends on both the geometry and material properties of the lesion. Yet, in the development of animal models of these lesions little attention has been given to the evaluation of their mechanical behavior. Our goal was to compare the multiaxial mechanical behavior of a canine vein pouch model to published data on veins and human aneurysms. Nine vein pouches were created surgically in six mongrel dogs by anastomosing a 2 cm segment of the external jugular vein to the common carotid artery in an end-to-side fashion. The lesions were harvested one week post-surgery and subjected to cyclic inflation tests using a custom system. Pressure-regional strain data revealed that vein pouch aneurysms are very extensible for pressures up to 30 mmHg, especially in the axial direction, but stiff thereafter. None of the lesions ruptured in vivo or during inflation tests. Based on these data, we conclude that the overall behavior of canine vein pouch lesions, at one week post-surgery, did not mimic well that of human aneurysms. Thus, there is a need to pursue modifications or other models for the purposes of clinically relevant studies of lesion growth, rupture, and treatment.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0161-6412
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
569-73
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Mechanical behavior of a vein pouch saccular aneurysm model.
pubmed:affiliation
Department of Mechanical Engineering, University of Maryland, Baltimore, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't