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rdf:type |
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lifeskim:mentions |
umls-concept:C0042774,
umls-concept:C0301872,
umls-concept:C0457454,
umls-concept:C0681850,
umls-concept:C0887947,
umls-concept:C1444662,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C2349001,
umls-concept:C2697811,
umls-concept:C2700400
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pubmed:issue |
6
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|
pubmed:dateCreated |
1999-10-13
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|
pubmed:abstractText |
Therapeutic intervention with highly active antiretroviral therapy (HAART) can lead to suppression of HIV-1 plasma viremia to undetectable levels for 3 or more years. However, adherence to complex drug regimens can prove problematic, and subjects may temporarily discontinue HAART for variable periods. We studied 6 HIV-1-infected individuals who stopped therapy. Off HAART, levels of viremia were suppressed to fewer than 500 copies/mL in 2 subjects for more than 12 and more than 24 months, respectively, and in 1 subject for 4 months on 1 occasion. Three subjects failed to contain plasma viremia. Broad and strong HIV-1-specific immune responses were detected in subjects with prolonged suppression of viral replication. This longitudinal study suggests that containment of HIV-1 replication to low or undetectable levels after discontinuation of HAART is associated with strong virus-specific immune responses. Boosting of HIV-1-specific immune responses should be considered as an adjunctive treatment strategy for HIV-1-infected individuals on HAART.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-10188643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-10203058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-10229227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-10341272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-10341273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-10357375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-10491402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-8057491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-8207839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-8638160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-8656501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-8780812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-8811338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9018240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9050875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9288048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9360926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9360927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9367954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9371822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9445059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9496965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9516110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9593437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9670036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9683211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9780251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9847391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9858507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9863885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9863886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10491418-9973442
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9738
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pubmed:author |
pubmed-author:BinleyJJ,
pubmed-author:BonhoefferSS,
pubmed-author:CamGG,
pubmed-author:CuqPP,
pubmed-author:DemoitieM AMA,
pubmed-author:DonahoeS MSM,
pubmed-author:FINKB WBW,
pubmed-author:HeymannJ JJJ,
pubmed-author:HurleyAA,
pubmed-author:JinXX,
pubmed-author:KakimotoW MWM,
pubmed-author:KhajaN UNU,
pubmed-author:KueblerP JPJ,
pubmed-author:MarkowitzMM,
pubmed-author:MooreJ PJP,
pubmed-author:NixonD FDF,
pubmed-author:OrtizG MGM,
pubmed-author:TrkolaAA,
pubmed-author:ZhangLL
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pubmed:issnType |
Print
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R13-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10491418-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:10491418-Adult,
pubmed-meshheading:10491418-Anti-HIV Agents,
pubmed-meshheading:10491418-HIV Core Protein p24,
pubmed-meshheading:10491418-HIV-1,
pubmed-meshheading:10491418-Humans,
pubmed-meshheading:10491418-Male,
pubmed-meshheading:10491418-Middle Aged,
pubmed-meshheading:10491418-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:10491418-Viremia,
pubmed-meshheading:10491418-Virus Replication
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pubmed:year |
1999
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pubmed:articleTitle |
HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy.
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pubmed:affiliation |
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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