Linked Life Data

10491282

Source:http://linkedlifedata.com/resource/pubmed/id/10491282

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-10-21
pubmed:abstractText
One mechanism for modification of glucose transport activity occurs through regulation of the cellular content of transporter protein by alteration of transcript stability. Regulated mRNA decay has been shown to play an important role in control of posttranscriptional gene expression. Implicated, as a pivotal element in this regulation is the 3'-untranslated region (UTR) of the message. Recent work from several labs has focused on sequence motifs within the 3'-UTR of glucose transporter (GLUT1) mRNA that serve as destabilizing or stabilizing elements and recognition of these elements by specific proteins. In this review, we address several critical studies each of which has identified elements in the GLUT1 3'-UTR that are involved in the control of transcript stability and demonstrated that these sequence motifs are recognized by specific binding proteins.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-291X
pubmed:author
pubmed:copyrightInfo
Copyright 1999 Academic Press.
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
263
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
265-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
The influence of mRNA stability on glucose transporter (GLUT1) gene expression.
pubmed:affiliation
School of Medicine, East Carolina University, Greenville, North Carolina, 27858-4354, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review