Linked Life Data

10490239

Source:http://linkedlifedata.com/resource/pubmed/id/10490239

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-10-27
pubmed:abstractText
Parkinson's disease is characterized by dopaminergic cell death in the substantia nigra. The underlying mechanism is, however, unknown. Though there are increasing lines of evidence showing iron accumulation in the Parkinsonian substantia nigra, it still remains obscure whether increased iron is the primary cause of dopaminergic cell death, or just a consequence of the pathological process. It is also unclear how iron gains access to the Parkinsonian SN. To gain more understanding in these areas, the present study investigated the time course of dopaminergic cell death and of changes in the level of iron, ferritin and transferrin. The results showed that iron was increased after the significant nigral dopaminergic cell death induced by 6-hydroxydopamine injection into the rat substantia nigra. On the other hand, the expression of transferrin was decreased. However, there was a temporal increase in the number of ferritin positive microglia. The results indicated that iron increase was not the primary cause of dopaminergic cell death in the Parkinsonian rat. It was most likely the result of an accumulation of iron-laden microglia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1071-5762
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
103-12
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Time course of dopaminergic cell death and changes in iron, ferritin and transferrin levels in the rat substantia nigra after 6-hydroxydopamine (6-OHDA) lesioning.
pubmed:affiliation
Department of Surgery, National University of Singapore, Singapore.
pubmed:publicationType
Journal Article