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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1999-10-1
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pubmed:abstractText |
SOCS1 is an SH2-containing protein that is primarily expressed in thymocytes in a cytokine- and T cell receptor-independent manner. SOCS1 deletion causes perinatal lethality with death by 2-3 weeks. During this period thymic changes include a loss of cellularity and a switch from predominantly CD4+ CD8+ to single positive cells. Peripheral T cells express activation antigens and proliferate to IL-2 in the absence of anti-CD3. In addition, IFNgamma is present in the serum. Reconstitution of the lymphoid lineage of JAK3-deficient mice with SOCS1-deficient stem cells recapitulates the lethality and T cell alterations. Introducing a RAG2 or IFNgamma deficiency eliminates lethality. The results demonstrate that lymphocytes are critical to SOCS1-associated perinatal lethality and implicate SOCS1 in lymphocyte differentiation or regulation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Jak3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Rag2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Socs1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Suppressor of Cytokine Signaling...,
http://linkedlifedata.com/resource/pubmed/chemical/V(D)J recombination activating...
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
609-16
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10490100-Age Factors,
pubmed-meshheading:10490100-Animals,
pubmed-meshheading:10490100-Animals, Newborn,
pubmed-meshheading:10490100-Carrier Proteins,
pubmed-meshheading:10490100-DNA-Binding Proteins,
pubmed-meshheading:10490100-Dose-Response Relationship, Drug,
pubmed-meshheading:10490100-Flow Cytometry,
pubmed-meshheading:10490100-Gene Expression Regulation, Developmental,
pubmed-meshheading:10490100-Interferon-gamma,
pubmed-meshheading:10490100-Janus Kinase 3,
pubmed-meshheading:10490100-Lymphocytes,
pubmed-meshheading:10490100-Mice,
pubmed-meshheading:10490100-Mice, Mutant Strains,
pubmed-meshheading:10490100-Protein-Tyrosine Kinases,
pubmed-meshheading:10490100-Repressor Proteins,
pubmed-meshheading:10490100-Suppressor of Cytokine Signaling Proteins,
pubmed-meshheading:10490100-T-Lymphocytes,
pubmed-meshheading:10490100-Thymus Gland,
pubmed-meshheading:10490100-Tissue Distribution
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pubmed:year |
1999
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pubmed:articleTitle |
SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality.
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pubmed:affiliation |
Howard Hughes Medical Institute, and Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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