Source:http://linkedlifedata.com/resource/pubmed/id/10490002
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
1999-9-30
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| pubmed:abstractText |
Semen is the body fluid most commonly associated with sexual transmission of human immunodeficiency virus type-1 (HIV-1). Because the male genitourinary tract is distinct immunologically from blood, compartment-dependent factors may determine HIV-1 shedding in semen. To identify these factors, the authors obtained 411 semen and blood specimens from 149 men seen up to three times. Seminal plasma was assayed for HIV-1 RNA and semen was cocultured for HIV-1 and cytomegalovirus (CMV), which may up-regulate HIV-1 replication. The best multivariate model for predicting a positive semen HIV-1 coculture included two local urogenital factors, increased seminal polymorphonuclear cell count (odds ratio (OR) = 12.6 for each log10 increase/mL, 95% confidence interval (CI) 12.2, 134.5) and a positive CMV coculture (OR = 3.0, 95% CI 1.2, 7.7). The best multivariate model for predicting semen HIV-1 RNA included two systemic host factors, CD4+ cell counts <200/microliter (OR = 3.0, 95 percent CI 1.3, 6.9) and nucleoside antiretroviral therapy (monotherapy: OR = 0.5, 95% CI 0.3, 1.0; combination therapy: OR = 0.4, 95% CI 0.2, 0.9), and a positive CMV coculture (OR = 1.7, 95% CI 1.0, 3.0). Thus, both systemic and local genitourinary tract factors influence the risk of semen HIV-1 shedding. These findings suggest that measures of systemic virus burden alone may not predict semen infectivity reliably.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0002-9262
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| pubmed:author |
pubmed-author:CentAA,
pubmed-author:CollierA CAC,
pubmed-author:CoombsR WRW,
pubmed-author:CoreyLL,
pubmed-author:DragavonJJ,
pubmed-author:HootonT MTM,
pubmed-author:JohnsonE JEJ,
pubmed-author:KoutskyL ALA,
pubmed-author:KriegerJ NJN,
pubmed-author:LeaSS,
pubmed-author:RossS OSO,
pubmed-author:SampoleoR RRR,
pubmed-author:SteinH IHI,
pubmed-author:ZehJJ
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
150
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
622-31
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| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:10490002-Adult,
pubmed-meshheading:10490002-CD4 Lymphocyte Count,
pubmed-meshheading:10490002-Coculture Techniques,
pubmed-meshheading:10490002-Cytomegalovirus,
pubmed-meshheading:10490002-Cytomegalovirus Infections,
pubmed-meshheading:10490002-HIV Infections,
pubmed-meshheading:10490002-HIV-1,
pubmed-meshheading:10490002-Homosexuality, Male,
pubmed-meshheading:10490002-Humans,
pubmed-meshheading:10490002-Logistic Models,
pubmed-meshheading:10490002-Male,
pubmed-meshheading:10490002-Middle Aged,
pubmed-meshheading:10490002-Predictive Value of Tests,
pubmed-meshheading:10490002-Prospective Studies,
pubmed-meshheading:10490002-RNA, Viral,
pubmed-meshheading:10490002-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10490002-Risk Factors,
pubmed-meshheading:10490002-Semen,
pubmed-meshheading:10490002-Virus Shedding
|
| pubmed:year |
1999
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| pubmed:articleTitle |
Risk factors for HIV-1 shedding in semen.
|
| pubmed:affiliation |
Department of Epidemiology, University of Washington, Seattle 98195, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|