Source:http://linkedlifedata.com/resource/pubmed/id/10488954
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1999-10-13
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pubmed:abstractText |
We have shown earlier that sitostanol ester margarine lowers serum cholesterol by inhibiting cholesterol absorption so that, theoretically, there could be interference with the absorption of fat-soluble vitamins. Accordingly, we investigated whether sitostanol ester margarine affects the serum levels of vitamin D, retinol, alpha-tocopherol and alpha- and beta-carotenes during 1-year treatment in 102 subjects and 49 controls with moderate hypercholesterolemia. The vitamins were assayed at baseline on home diet, on margarine alone, after 1 year's consumption of sitostanol ester margarine and after an additional 2 months on home diet. In the sitostanol group, serum plant sterols, indicators of cholesterol absorption efficiency, were reduced up to -38% in relation to controls from home diet (P < 0.01) indicating that cholesterol absorption was markedly reduced. Vitamin D and retinol concentrations and the ratio of alpha-tocopherol to cholesterol were unchanged by sitostanol ester. Serum beta-carotenes and alpha-carotene concentration but not proportion were reduced in the sitostanol group from baseline and in relation to controls (P < 0.01). Retinol and vitamin D were unassociated with serum cholesterol, plant sterols or other vitamins, whereas alpha-tocopherol and carotenes were significantly associated with serum plant sterols suggesting that the higher cholesterol absorption efficiency, the higher the alpha-tocopherol and carotene levels in serum. We conclude that sitostanol ester did not affect vitamin D and retinol concentrations and alpha-tocopherol/cholesterol proportion, but reduced serum beta-carotene levels. Alpha-tocopherol and carotenes, but not vitamin D and retinol, were related to serum cholesterol and cholesterol absorption.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anticholesteremic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Carotenoids,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Margarine,
http://linkedlifedata.com/resource/pubmed/chemical/Sitosterols,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin A,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin D,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E,
http://linkedlifedata.com/resource/pubmed/chemical/beta Carotene,
http://linkedlifedata.com/resource/pubmed/chemical/stigmastanol
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9150
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
145
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
279-85
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10488954-Adult,
pubmed-meshheading:10488954-Anticholesteremic Agents,
pubmed-meshheading:10488954-Carotenoids,
pubmed-meshheading:10488954-Cholesterol,
pubmed-meshheading:10488954-Chromatography, High Pressure Liquid,
pubmed-meshheading:10488954-Dietary Fats,
pubmed-meshheading:10488954-Double-Blind Method,
pubmed-meshheading:10488954-Humans,
pubmed-meshheading:10488954-Hypercholesterolemia,
pubmed-meshheading:10488954-Intestinal Absorption,
pubmed-meshheading:10488954-Margarine,
pubmed-meshheading:10488954-Middle Aged,
pubmed-meshheading:10488954-Sitosterols,
pubmed-meshheading:10488954-Vitamin A,
pubmed-meshheading:10488954-Vitamin D,
pubmed-meshheading:10488954-Vitamin E,
pubmed-meshheading:10488954-beta Carotene
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pubmed:year |
1999
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pubmed:articleTitle |
Retinol, vitamin D, carotenes and alpha-tocopherol in serum of a moderately hypercholesterolemic population consuming sitostanol ester margarine.
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pubmed:affiliation |
Department of Medicine, University of Helsinki, Finland.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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