Linked Life Data

10487490

Source:http://linkedlifedata.com/resource/pubmed/id/10487490

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-10-28
pubmed:abstractText
Gender is a strong predictor of coronary heart disease (CHD) susceptibility and reports indicate that males are more likely to develop CHD compared to age-matched premenopausal females. To test whether similar gender differences exist in hamsters, 16 male and 16 female F1B Golden Syrian hamsters, aged 10 weeks, were fed a hypercholesterolemic nonpurified diet (HCD) containing 10% coconut oil and 0.05% cholesterol for 12 weeks. Plasma lipid and lipoprotein cholesterol concentrations, LDL oxidative susceptibility, LDL tocopherol concentrations, LDL fatty acid composition, LDL particle size, plasma estradiol and testosterone concentrations, and early aortic atherosclerosis were analyzed. Female hamsters had significantly lower plasma total cholesterol and nonhigh-density lipoprotein cholesterol (nonHDL-C) and greater high-density lipoprotein cholesterol (HDL-C) concentrations compared to male hamsters (-15, -33, and 33%; respectively). Female hamsters had significantly greater LDL particle size (4%), LDL 22:6 (21%) fatty acid, and rate of LDL oxidation (34%) compared to male hamsters. Female hamsters had a significantly higher concentration of plasma estradiol (49%) compared to male hamsters. Female hamsters also had significantly less early aortic atherosclerosis compared to male hamsters (-77%). In female hamsters, aortic fatty streak formation was significantly associated with plasma nonHDL-C (r = 0.76, P<0.0007), LDL particle size (r = -0.66, P<0.005), plasma TC (r = 0.68. P<0.004), and lag phase of LDL oxidation (r = 0.84. P<0.02). In male hamsters, aortic fatty streak formation was significantly associated with plasma nonHDL-C (r = 0.52, P<0.04), plasma TC (r = 0.55, P<0.03), plasma TG (r = 0.79, P<0.0003), and LDL 22:6 (r = -0.78, P<0.03) with no association with any measures of LDL oxidation susceptibility. This study demonstrates that female hamsters have an improved plasma lipoprotein cholesterol profile, larger LDL particle size, and less early aortic atherosclerosis compared to male hamsters fed the same HCD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-9150
pubmed:author
pubmed:issnType
Print
pubmed:volume
146
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-91
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10487490-Animals, pubmed-meshheading:10487490-Aorta, Thoracic, pubmed-meshheading:10487490-Arteriosclerosis, pubmed-meshheading:10487490-Body Weight, pubmed-meshheading:10487490-Cholesterol, Dietary, pubmed-meshheading:10487490-Cholesterol, HDL, pubmed-meshheading:10487490-Cholesterol, LDL, pubmed-meshheading:10487490-Chromatography, High Pressure Liquid, pubmed-meshheading:10487490-Cricetinae, pubmed-meshheading:10487490-Disease Models, Animal, pubmed-meshheading:10487490-Estradiol, pubmed-meshheading:10487490-Fatty Acids, pubmed-meshheading:10487490-Female, pubmed-meshheading:10487490-Hypercholesterolemia, pubmed-meshheading:10487490-Male, pubmed-meshheading:10487490-Mesocricetus, pubmed-meshheading:10487490-Sensitivity and Specificity, pubmed-meshheading:10487490-Sex Factors, pubmed-meshheading:10487490-Testosterone, pubmed-meshheading:10487490-Triglycerides
pubmed:year
1999
pubmed:articleTitle
Gender differences in response to a hypercholesterolemic diet in hamsters: effects on plasma lipoprotein cholesterol concentrations and early aortic atherosclerosis.
pubmed:affiliation
Department of Health and Clinical Science, Center for Chronic Disease Control, University of Massachusetts Lowell 01854, USA.
pubmed:publicationType
Journal Article, Comparative Study