Source:http://linkedlifedata.com/resource/pubmed/id/10487487
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1999-10-28
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pubmed:abstractText |
Squalene, found in earlier studies in human atherosclerotic plaques, was measured in the serum of postmenopausal women with coronary artery disease (CAD) (n = 25) and randomly chosen age-matched healthy controls (n = 30). The squalene concentrations of the whole population ranged from 37.5 to 115.5 microg/dl, and were higher in serum of the CAD than healthy women (91.4+/-2.6 versus 65.2+/-2.6 microg/dl, P = 0.000), a finding observed also in relation to cholesterol (43.8+/-1.8 versus 32.9+/-1.1 10(2)x mmol/mol of cholesterol, P = 0.000). The squalene concentration was also increased in chylomicrons, VLDL and d>1.006 g/ml lipoproteins, and the proportions to cholesterol in VLDL and d>1.006 g/ml lipoproteins. The respective squalene and cholesterol concentrations were related to each other in serum, VLDL and d>1.006 g/ml lipoproteins (r = 0.52, 0.85 and 0.55, respectively), whereas the correlation with triglycerides was seen only in VLDL (r = 0.84) over the whole population. Besides enhanced intestinal secretion, it remains to be shown whether higher serum squalene in postmenopausal coronary women is due to increased cholesterol synthesis or a defect in squalene conversion to lanosterol.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9150
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
146
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
61-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10487487-Biological Markers,
pubmed-meshheading:10487487-Cholesterol,
pubmed-meshheading:10487487-Coronary Disease,
pubmed-meshheading:10487487-Female,
pubmed-meshheading:10487487-Humans,
pubmed-meshheading:10487487-Linear Models,
pubmed-meshheading:10487487-Lipoproteins, VLDL,
pubmed-meshheading:10487487-Middle Aged,
pubmed-meshheading:10487487-Postmenopause,
pubmed-meshheading:10487487-Reference Values,
pubmed-meshheading:10487487-Sensitivity and Specificity,
pubmed-meshheading:10487487-Squalene,
pubmed-meshheading:10487487-Statistics, Nonparametric
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pubmed:year |
1999
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pubmed:articleTitle |
Serum squalene in postmenopausal women without and with coronary artery disease.
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pubmed:affiliation |
Department of Medicine, University of Helsinki, Finland.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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