Source:http://linkedlifedata.com/resource/pubmed/id/10484466
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3 Pt 1
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pubmed:dateCreated |
1999-10-28
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pubmed:abstractText |
Surfactant protein A (SP-A) is a member of the collectin family of host defense molecules expressed primarily in the epithelial cells of the lung. To determine the role of SP-A in pulmonary adenoviral infection, SP-A-deficient (SP-A -/-) mice were intratracheally infected with a replication-deficient recombinant adenovirus, Av1Luc1. Lung inflammation was markedly increased in SP-A -/- compared with SP-A +/+ mice and was associated with increased hemorrhage and epithelial cell injury. Polymorphonuclear cells in bronchoalveolar lavage fluid (BALF) were increased in SP-A -/- mice after administration of adenovirus. Coadministration of adenovirus and purified human SP-A ameliorated adenoviral-induced lung inflammation in SP-A -/- mice. Concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and IL-1beta were increased in BALF of SP-A -/- mice. Likewise, TNF-alpha, IL-6, macrophage inflammatory protein (MIP)-1alpha, monocyte chemotactic protein-1, and MIP-2 mRNAs were increased in lung homogenates from SP-A -/- mice 6 and 24 h after viral administration. Clearance of adenoviral DNA from the lung and uptake of fluorescent-labeled adenovirus by alveolar macrophages were decreased in SP-A -/- mice. SP-A enhances viral clearance and inhibits lung inflammation during pulmonary adenoviral infection, providing support for the importance of SP-A in antiviral host defense.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Proteolipids,
http://linkedlifedata.com/resource/pubmed/chemical/Pulmonary Surfactant-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Pulmonary Surfactant-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Pulmonary Surfactants
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0002-9513
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
277
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
L580-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10484466-Adenoviridae,
pubmed-meshheading:10484466-Adenoviridae Infections,
pubmed-meshheading:10484466-Animals,
pubmed-meshheading:10484466-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:10484466-Cytokines,
pubmed-meshheading:10484466-Humans,
pubmed-meshheading:10484466-Lung,
pubmed-meshheading:10484466-Macrophages, Alveolar,
pubmed-meshheading:10484466-Mice,
pubmed-meshheading:10484466-Mice, Inbred Strains,
pubmed-meshheading:10484466-Mice, Knockout,
pubmed-meshheading:10484466-Pneumonia,
pubmed-meshheading:10484466-Proteolipids,
pubmed-meshheading:10484466-Pulmonary Surfactant-Associated Protein A,
pubmed-meshheading:10484466-Pulmonary Surfactant-Associated Proteins,
pubmed-meshheading:10484466-Pulmonary Surfactants
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pubmed:year |
1999
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pubmed:articleTitle |
SP-A enhances viral clearance and inhibits inflammation after pulmonary adenoviral infection.
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pubmed:affiliation |
Children's Hospital Medical Center, Division of Neonatology and Pulmonary Biology, Cincinnati, Ohio 45229, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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