Linked Life Data

10483236

Source:http://linkedlifedata.com/resource/pubmed/id/10483236

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1999-10-12
pubmed:abstractText
There is a growing consensus that autoimmune thyroid diseases, similar to other autoimmune diseases, is multifactorial: both several genetic and environmental factors interact and produce the clinical phenotype of these disorders. Twin studies and familial aggregation, including clustering within families showed that they are complex diseases with a significant genetic component. Several genetic factors associated with autoimmune thyroid diseases susceptibility have been identified, including the HLA genes, cytotoxic T lymphocyte associated-4 (CTLA-4) gene, TSH receptor and other immunoregulatory genes. Regarding environmental factors, although multiple factors including infection, stress, sex steroids, pregnancy, aging and food, are known as factors precipitating autoimmune thyroid diseases, little progress has been achieved defining them. It will be paradoxically important to identify genetic factors to investigate environmental factors.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1697-702
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
[Genetic and environmental factors of autoimmune thyroid diseases].
pubmed:affiliation
Department of Medicine & Clinical Science, Kyoto University Graduate School of Medicine.
pubmed:publicationType
Journal Article, English Abstract, Review