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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1999-10-12
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pubmed:abstractText |
Cytotoxic T lymphocyte (CTL) responses against the simian immunodeficiency virus (SIV) envelope and Gag proteins were monitored in a Mamu-A*01-positive rhesus macaque infected with SIVsmE660. Peripheral blood mononuclear cells (PBMC) cultured with synthetic peptides spanning the entire gp160 and Gag coding region recognized a total of three epitopes. One located in Gag was identified as the previously described Mamu-A*01-restricted p11cC-->M epitope (CTPYDINQM). The other two epitopes, designated p15m and p54m, were located in the gp160 envelope protein. Both were nine amino acids in length and were predicted to bind Mamu-A*01 because they contained proline and leucine residues at positions 3 and 9, respectively. Indeed, expression of this class I major histocompatibility complex molecule was required for target cell recognition by envelope-specific CD8(+) T cells directed against both epitopes. These Mamu-A*01-restricted epitopes in the SIV envelope will be useful for monitoring immune responses in vaccinated or infected animals.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-1711081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-2019773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-2431484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-2497065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-2784486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-2786147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-7511178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-7521921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-8067053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-8717519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-8794394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-9060675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-9345075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-9458122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-9516110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-9565629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-9565630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-9637523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-9883837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-9933172
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8035-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10482552-Amino Acid Sequence,
pubmed-meshheading:10482552-Animals,
pubmed-meshheading:10482552-Antigens, Viral,
pubmed-meshheading:10482552-Cytotoxicity, Immunologic,
pubmed-meshheading:10482552-Epitopes,
pubmed-meshheading:10482552-Macaca mulatta,
pubmed-meshheading:10482552-Molecular Sequence Data,
pubmed-meshheading:10482552-Simian immunodeficiency virus,
pubmed-meshheading:10482552-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:10482552-Viral Envelope Proteins
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pubmed:year |
1999
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pubmed:articleTitle |
The simian immunodeficiency virus envelope glycoprotein contains two epitopes presented by the Mamu-A*01 class I molecule.
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pubmed:affiliation |
Children's Research Institute, Children's Hospital, Inc., Department of Pediatrics, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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