Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1999-9-20
pubmed:abstractText
GFR alpha3 is a component of the receptor for the neurotrophic factor artemin. The role of GFR alpha3 in nervous system development was examined by generating mice in which the Gfr alpha3 gene was disrupted. The Gfr alpha3-/- mice exhibited severe defects in the superior cervical ganglion (SCG), whereas other ganglia appeared normal. SCG precursor cells in the mutant embryos failed to migrate to the correct position, and they subsequently failed to innervate the target organs. In wild-type embryos, Gfr alpha3 was expressed in migrating SCG precursors, and artemin was expressed in and near the SCG. After birth, SCG neurons in the mutant mice underwent progressive cell death. These observations suggest that GFR alpha3-mediated signaling is required both for the rostral migration of SCG precursors and for the survival of mature SCG neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0896-6273
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
725-36
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:10482239-Animals, pubmed-meshheading:10482239-Cell Death, pubmed-meshheading:10482239-Cell Movement, pubmed-meshheading:10482239-Cell Survival, pubmed-meshheading:10482239-Drosophila Proteins, pubmed-meshheading:10482239-Genotype, pubmed-meshheading:10482239-Immunohistochemistry, pubmed-meshheading:10482239-In Situ Hybridization, pubmed-meshheading:10482239-Mice, pubmed-meshheading:10482239-Mice, Knockout, pubmed-meshheading:10482239-Nerve Growth Factors, pubmed-meshheading:10482239-Nerve Tissue Proteins, pubmed-meshheading:10482239-Neurons, pubmed-meshheading:10482239-Proto-Oncogene Proteins, pubmed-meshheading:10482239-Proto-Oncogene Proteins c-ret, pubmed-meshheading:10482239-Receptor Protein-Tyrosine Kinases, pubmed-meshheading:10482239-Receptors, Nerve Growth Factor, pubmed-meshheading:10482239-Superior Cervical Ganglion
pubmed:year
1999
pubmed:articleTitle
GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion.
pubmed:affiliation
Division of Molecular Biology, Institute for Molecular and Cellular Biology, Osaka University, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't