10480874

Source:http://linkedlifedata.com/resource/pubmed/id/10480874

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0024662, umls-concept:C0040649, umls-concept:C0086860, umls-concept:C0597519, umls-concept:C0599739, umls-concept:C1167622, umls-concept:C1564673
pubmed:issue	38
pubmed:dateCreated	1999-10-13
pubmed:abstractText	Transcriptional synergism between glucocorticoid receptor (GR) and octamer transcription factors 1 and 2 (Oct-1 and Oct-2) in the induction of mouse mammary tumor virus (MMTV) transcription has been proposed to be mediated through directed recruitment of the octamer factors to their binding sites in the viral long terminal repeat. This recruitment correlates with direct binding between the GR DNA binding domain and the POU domain of the octamer factors. In present study, in vitro experiments identified several nuclear hormone receptors to have the potential to bind to the POU domains of Oct-1 and Oct-2 through their DNA binding domains, suggesting that POU domain binding may be a property shared by many nuclear hormone receptors. However, physiologically relevant binding to the POU domain appeared to be a property restricted to only a few nuclear receptors as only GR, progesterone receptor (PR), and androgen receptor (AR), were found to interact physically and functionally with Oct-1 and Oct-2 in transfected cells. Thus GR, PR, and AR efficiently promoted the recruitment of Oct-2 to adjacent octamer motifs in the cell, whereas mineralocorticoid receptor (MR), estrogen receptor alpha, and retinoid X receptor failed to facilitate octamer factor DNA binding. For MMTV, although GR and MR both induced transcription efficiently, mutation of the promoter proximal octamer motifs strongly decreased GR-induced transcription without affecting the total level of reporter gene activity in response to MR. These results suggest that the configuration of the hormone response element within the MMTV long terminal repeat may promote a dependence for the glucocorticoid response upon the recruitment of octamer transcription factors to their response elements within the viral promoter.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2985121R
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Hcfc1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Host Cell Factor C1, http://linkedlifedata.com/resource/pubmed/chemical/Octamer Transcription Factor-1, http://linkedlifedata.com/resource/pubmed/chemical/Octamer Transcription Factor-2, http://linkedlifedata.com/resource/pubmed/chemical/Pou2f1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Pou2f2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glucocorticoid, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Mineralocorticoid, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/retinoic acid receptor alpha
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0021-9258
pubmed:author	pubmed-author:GiffinWW, pubmed-author:HachéR JRJ, pubmed-author:LemieuxM EME, pubmed-author:PoppGG, pubmed-author:PréfontaineG GGG, pubmed-author:WaltherRR
pubmed:issnType	Print
pubmed:day	17
pubmed:volume	274
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	26713-9
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:10480874-Animals, pubmed-meshheading:10480874-Binding Sites, pubmed-meshheading:10480874-DNA, Viral, pubmed-meshheading:10480874-DNA-Binding Proteins, pubmed-meshheading:10480874-Drosophila, pubmed-meshheading:10480874-Fibroblasts, pubmed-meshheading:10480874-Host Cell Factor C1, pubmed-meshheading:10480874-Mammary Tumor Virus, Mouse, pubmed-meshheading:10480874-Mice, pubmed-meshheading:10480874-Octamer Transcription Factor-1, pubmed-meshheading:10480874-Octamer Transcription Factor-2, pubmed-meshheading:10480874-Promoter Regions, Genetic, pubmed-meshheading:10480874-Protein Folding, pubmed-meshheading:10480874-Rabbits, pubmed-meshheading:10480874-Receptors, Glucocorticoid, pubmed-meshheading:10480874-Receptors, Mineralocorticoid, pubmed-meshheading:10480874-Receptors, Retinoic Acid, pubmed-meshheading:10480874-Transcription, Genetic, pubmed-meshheading:10480874-Transcription Factors, pubmed-meshheading:10480874-Transcriptional Activation
pubmed:year	1999
pubmed:articleTitle	Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter.
pubmed:affiliation	Graduate Program in Biochemistry, University of Ottawa, Loeb Institute for Medical Research, Ottawa Civic Hospital, Ottawa K1Y 4E9, Ontario, Canada.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't