Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-10-19
pubmed:abstractText
Nitrated nonivamide (NVANO)-induced triad hypotension, and biphasic bradycardia at 0.25-1.0 mg/kg (IV) was inhibited by capsazepine (1.0 mg/kg, IV), atropine (1.0 mg/kg, IV), and vagotomy in rats. NVANO also elicited a hypotensive spinal reflex at 5.0 mg/kg (IA). In the isolated rat vagus, NVANO (10.0-100.0 microM) revealed a sensory C-spike inhibition and membrane depolarization. NVANO (5.0 microM)-induced calcium influx in the isolated rat dorsal root ganglion cells (DRGs) was diminished by capsazepine (10.0 microM). In the isolated guinea pig atria, NVANO (1.0-50.0 microM)-induced positive inotropic and chronotropic activities were antagonized by capsazepine (1.0-10.0 microM) and human calcitonin gene-related peptide(8-37) (hCGRP(837); 0.1-1.0 microM).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0306-3623
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
257-69
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:10480659-Action Potentials, pubmed-meshheading:10480659-Amides, pubmed-meshheading:10480659-Animals, pubmed-meshheading:10480659-Blood Pressure, pubmed-meshheading:10480659-Calcitonin Gene-Related Peptide, pubmed-meshheading:10480659-Calcium, pubmed-meshheading:10480659-Capsaicin, pubmed-meshheading:10480659-Dose-Response Relationship, Drug, pubmed-meshheading:10480659-Enzyme Inhibitors, pubmed-meshheading:10480659-Ganglia, Sensory, pubmed-meshheading:10480659-Ganglia, Spinal, pubmed-meshheading:10480659-Guinea Pigs, pubmed-meshheading:10480659-Heart Rate, pubmed-meshheading:10480659-Humans, pubmed-meshheading:10480659-Male, pubmed-meshheading:10480659-Myocardial Contraction, pubmed-meshheading:10480659-Neurons, pubmed-meshheading:10480659-Nitrates, pubmed-meshheading:10480659-Protons, pubmed-meshheading:10480659-Rats, pubmed-meshheading:10480659-Rats, Wistar, pubmed-meshheading:10480659-Vagotomy, pubmed-meshheading:10480659-Vagus Nerve, pubmed-meshheading:10480659-Vanillic Acid
pubmed:year
1999
pubmed:articleTitle
Nitrated nonivamide displaying a drawback of proton's role in capsaicin-associated sensory and neuronal activities.
pubmed:affiliation
Department of Pharmacology, Graduate Institute of Medicine, Kaohsiung Medical College, Taiwan.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't