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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1999-9-27
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pubmed:abstractText |
A novel class of macrolides, the sanglifehrins, was discovered by screening of actinomycete strains with a cyclophilin-binding assay. The chemical structures and absolute stereochemistries of the sanglifehrins A, B, C and D were determined unambiguously by NMR-techniques and by X-ray crystallography of the complex with cyclophilin A. Sanglifehrin A consists of a 22-membered macrocycle containing a tripeptide subunit and features in position 23 a chain of nine carbon atoms bearing a spirocyclic substituent. Sanglifehrins A and B are genuine metabolites whereas sanglifehrins C and D are artefacts.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
474-9
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:10480571-Anti-Bacterial Agents,
pubmed-meshheading:10480571-Crystallography, X-Ray,
pubmed-meshheading:10480571-Immunosuppressive Agents,
pubmed-meshheading:10480571-Lactones,
pubmed-meshheading:10480571-Macrolides,
pubmed-meshheading:10480571-Magnetic Resonance Spectroscopy,
pubmed-meshheading:10480571-Molecular Conformation,
pubmed-meshheading:10480571-Molecular Structure,
pubmed-meshheading:10480571-Peptidylprolyl Isomerase,
pubmed-meshheading:10480571-Spiro Compounds,
pubmed-meshheading:10480571-Streptomyces
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pubmed:year |
1999
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pubmed:articleTitle |
Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92-308110. II. Structure elucidation, stereochemistry and physico-chemical properties.
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pubmed:affiliation |
Novartis Pharma Inc., Research, Department of Core Technology, Basel, Switzerland.
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pubmed:publicationType |
Journal Article
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