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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1999-11-19
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pubmed:abstractText |
This study was designed to examine the relationship between the antidiarrhoeal effects of Hange-Shashin-To (TJ-14) and its active components. Oral treatment with TJ-14 at 1000 mg/kg significantly inhibited castor oil-induced diarrhoea. Both the 50% methanol eluate fraction (fraction III) and the methanol eluate fraction (fraction IV) showed antidiarrhoeal effects at oral doses of 68 mg/kg and 63 mg/kg, respectively, corresponding to 1000 mg/kg of TJ-14. TJ-14 (1000 mg/kg, p.o.) showed a significant increase in blood corticosterone levels. Increased blood corticosterone was noted after the oral administration of 63 mg/kg of fraction IV. The inhibitory activity of TJ-14 on cyclooxygenase-2 (COX-2) was also observed in fractions III and IV. The main component of fraction III was Scutellariae Radix-derived baicalin. Fraction IV contained Glycyrrhizae Radix-derived glycyrrhizin and isoliquiritin, Coptidis Rhizoma-derived berberine, coptisine and palmitine. Ginseng Radix-derived saponins were also present in fraction IV. These compounds inhibited castor-oil induced diarrhoea at oral doses of 10 or 30 mg/kg. Thus, the present results indicate that Scutellariae Radix, Glycyrrhizae Radix, Ginseng radix and Coptidis Rhizoma-derived components are involved in the antidiarrhoeal action of TJ-14.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antidiarrheals,
http://linkedlifedata.com/resource/pubmed/chemical/Castor Oil,
http://linkedlifedata.com/resource/pubmed/chemical/Corticosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Loperamide,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0951-418X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1999 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
468-73
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:10479755-Animals,
pubmed-meshheading:10479755-Antidiarrheals,
pubmed-meshheading:10479755-Castor Oil,
pubmed-meshheading:10479755-Corticosterone,
pubmed-meshheading:10479755-Cyclooxygenase 2,
pubmed-meshheading:10479755-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:10479755-Cyclooxygenase Inhibitors,
pubmed-meshheading:10479755-Diarrhea,
pubmed-meshheading:10479755-Indomethacin,
pubmed-meshheading:10479755-Isoenzymes,
pubmed-meshheading:10479755-Japan,
pubmed-meshheading:10479755-Loperamide,
pubmed-meshheading:10479755-Male,
pubmed-meshheading:10479755-Medicine, Kampo,
pubmed-meshheading:10479755-Mice,
pubmed-meshheading:10479755-Mice, Inbred ICR,
pubmed-meshheading:10479755-Plant Extracts,
pubmed-meshheading:10479755-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:10479755-Rats,
pubmed-meshheading:10479755-Rats, Wistar
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pubmed:year |
1999
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pubmed:articleTitle |
Relationship between the antidiarrhoeal effects of Hange-Shashin-To and its active components.
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pubmed:affiliation |
Kampo and Pharmacognosy Laboratory, Central Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan.
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pubmed:publicationType |
Journal Article
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