Source:http://linkedlifedata.com/resource/pubmed/id/10478716
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0011155,
umls-concept:C0021745,
umls-concept:C0035015,
umls-concept:C0040732,
umls-concept:C0450127,
umls-concept:C0681797,
umls-concept:C0871261,
umls-concept:C0936012,
umls-concept:C1423842,
umls-concept:C1548437,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1882923,
umls-concept:C2911692
|
| pubmed:issue |
4
|
| pubmed:dateCreated |
1999-10-20
|
| pubmed:abstractText |
The rejection mechanisms for fetal proislet allografts and pig proislet xenografts in mice are characterized by different intragraft cytokine mRNA profiles and cellular responses. Allograft rejection is predominantly CD8 T-cell-dependent and is associated with a Th1-type cytokine pattern (i.e., IFN-gamma, IL-2 but no IL-4 or IL-5 mRNA). In contrast, xenograft rejection is CD4 T-cell-dependent and is accompanied by a strong Th2-type response (i.e., enhanced expression of IL-4 and IL-5 mRNA) and by marked eosinophil accumulation at the graft site. We have now examined and compared the regulatory role of IFN-gamma in both proislet allograft and xenograft rejection processes. The histopathology and intragraft cytokine mRNA profile of BALB/c (H-2d) proislet allografts were examined in IFN-gamma-deficient and wild-type C57BL/6J recipient mice. The survival of pig proislet xenografts was also assessed in IFN-gamma -/- and wild-type hosts. Both proislet allografts and xenografts were acutely rejected in IFN-gamma -/- and wild-type mice. Unlike the conventional allograft reaction, which lacks eosinophil infiltration, the rejection of proislet allografts in IFN-gamma-deficient hosts correlated with intragraft expression of IL-4 and IL-5 mRNA (i.e., a Th2-type response) and eosinophil recruitment. The rejection of proislet allografts and xenografts can therefore occur by IFN-gamma-independent pathways; IFN-gamma, however, regulates the pathology of the allograft reaction but not the xenograft response. The immune destruction of proislet allografts is not prevented by Th2 cytokine gene expression; instead, the latter correlated with the recruitment of unconventional inflammatory cells (eosinophils), which may play an accessory role in effecting graft injury. Significantly, the Th1-to-Th2-like switch resulted in the novel conversion of an allograft rejection reaction into a xenograft-like rejection process.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0963-6897
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
365-73
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:10478716-Acute Disease,
pubmed-meshheading:10478716-Animals,
pubmed-meshheading:10478716-DNA Probes,
pubmed-meshheading:10478716-Female,
pubmed-meshheading:10478716-Gene Expression,
pubmed-meshheading:10478716-Graft Rejection,
pubmed-meshheading:10478716-Interferon-gamma,
pubmed-meshheading:10478716-Islets of Langerhans Transplantation,
pubmed-meshheading:10478716-Male,
pubmed-meshheading:10478716-Mice,
pubmed-meshheading:10478716-Mice, Inbred BALB C,
pubmed-meshheading:10478716-Mice, Inbred C57BL,
pubmed-meshheading:10478716-Mice, Knockout,
pubmed-meshheading:10478716-RNA, Messenger,
pubmed-meshheading:10478716-Swine,
pubmed-meshheading:10478716-Th1 Cells,
pubmed-meshheading:10478716-Th2 Cells,
pubmed-meshheading:10478716-Transcription, Genetic,
pubmed-meshheading:10478716-Transplantation, Heterologous,
pubmed-meshheading:10478716-Transplantation, Homologous
|
| pubmed:articleTitle |
Analysis of the Th1/Th2 paradigm in transplantation: interferon-gamma deficiency converts Th1-type proislet allograft rejection to a Th2-type xenograft-like response.
|
| pubmed:affiliation |
Division of Molecular Medicine, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT. Charmaine.Simeonovic@anu.edu.au
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|