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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1999-9-29
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pubmed:databankReference |
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pubmed:abstractText |
The ETV6 gene (also known as TEL) is the main target of chromosomal translocations affecting chromosome band 12p13. The rearrangements fuse ETV6 to a wide variety of partner genes in both myeloid and lymphoid malignancies. We report here 4 new cases of acute myeloid leukemia (AML) with very immature myeloblasts (French-American-British [FAB]-M0) and with a t(4;12)(q11-q12;p13). In all cases, ETV6 was found recombined to a new gene, homologous to the mouse Brx gene. The gene was named BTL (Brx-like Translocated in Leukemia). Reverse transcriptase-polymerase chain reaction (RT-PCR) experiments indicate that the expression of the BTL-ETV6 transcript, but not of the reciprocal ETV6-BTL transcript, is a common finding in these leukemias. In contrast to the majority of other ETV6 fusions, both the complete helix-loop-helix (HLH) and ETS DNA binding domains of ETV6 are present in the predicted BTL-ETV6 fusion protein, and the chimeric gene is transcribed from the BTL promoter.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-4971
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1820-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10477709-Acute Disease,
pubmed-meshheading:10477709-Adult,
pubmed-meshheading:10477709-Aged,
pubmed-meshheading:10477709-Aged, 80 and over,
pubmed-meshheading:10477709-Amino Acid Sequence,
pubmed-meshheading:10477709-Animals,
pubmed-meshheading:10477709-Base Sequence,
pubmed-meshheading:10477709-Chromosomes, Human, Pair 12,
pubmed-meshheading:10477709-Chromosomes, Human, Pair 4,
pubmed-meshheading:10477709-DNA-Binding Proteins,
pubmed-meshheading:10477709-Female,
pubmed-meshheading:10477709-Humans,
pubmed-meshheading:10477709-Leukemia, Myeloid,
pubmed-meshheading:10477709-Male,
pubmed-meshheading:10477709-Mice,
pubmed-meshheading:10477709-Middle Aged,
pubmed-meshheading:10477709-Molecular Sequence Data,
pubmed-meshheading:10477709-Oncogene Proteins, Fusion,
pubmed-meshheading:10477709-Proto-Oncogene Proteins c-ets,
pubmed-meshheading:10477709-Repressor Proteins,
pubmed-meshheading:10477709-Transcription Factors,
pubmed-meshheading:10477709-Translocation, Genetic
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pubmed:year |
1999
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pubmed:articleTitle |
Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13).
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pubmed:affiliation |
Center for Human Genetics, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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