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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
1999-10-14
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pubmed:abstractText |
A tetraphenylporphyrin-C11-beta-estradiol conjugate has been synthesized. Competitive binding assay of the conjugate with estrogen receptor (ER)-ligand-binding domain showed that the conjugate binds specifically to the protein with high affinity. Potential use of this conjugate to selectively deliver cytotoxic porphyrins to ER-positive cells in various carcinomas is discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0960-894X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2379-84
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10476873-Animals,
pubmed-meshheading:10476873-Breast Neoplasms,
pubmed-meshheading:10476873-Cattle,
pubmed-meshheading:10476873-Estradiol,
pubmed-meshheading:10476873-Female,
pubmed-meshheading:10476873-Humans,
pubmed-meshheading:10476873-Ovarian Neoplasms,
pubmed-meshheading:10476873-Photochemotherapy,
pubmed-meshheading:10476873-Porphyrins,
pubmed-meshheading:10476873-Protein Binding,
pubmed-meshheading:10476873-Receptors, Estrogen,
pubmed-meshheading:10476873-Spectrometry, Fluorescence,
pubmed-meshheading:10476873-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
Synthesis and estrogen receptor binding affinity of a porphyrin-estradiol conjugate for targeted photodynamic therapy of cancer.
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pubmed:affiliation |
Department of Medicine, Boston University School of Medicine, MA 02118, USA.
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pubmed:publicationType |
Journal Article
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