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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-12-2
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pubmed:abstractText |
Four hundred forty-eight patients with 929 Echinococcus granulosus hydatid cysts received 3- to 6-month continuous cycles of mebendazole or albendazole treatment and underwent prolonged follow-up by clinical visits and imaging studies (range, 1-14 years) to assess the long-term outcome of treatment. Degenerative changes and relapse were assessed by imaging techniques. At the end of therapy, 74.1% of the hydatid cysts showed degenerative changes. These were more frequent in albendazole-treated than in mebendazole-treated cysts (82.2% vs. 56.1%; P < .001). During long-term follow-up, 104 cysts (22%) had degenerative changes that progressed, whereas 163 cysts (approximately 25%) relapsed. The percentages of relapses in the two drug-treated groups were almost the same. Relapses occurred more frequently in type II cysts of the liver. Cysts recurred most often (78.5%; P < .001) within the first 2 years after treatment ended. Further chemotherapy cycles induced degenerative changes in >90% of relapsed cysts without inducing more frequent or more severe side effects than those observed during the initial cycles.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1058-4838
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
304-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10476732-Adolescent,
pubmed-meshheading:10476732-Adult,
pubmed-meshheading:10476732-Aged,
pubmed-meshheading:10476732-Aged, 80 and over,
pubmed-meshheading:10476732-Albendazole,
pubmed-meshheading:10476732-Animals,
pubmed-meshheading:10476732-Anthelmintics,
pubmed-meshheading:10476732-Benzimidazoles,
pubmed-meshheading:10476732-Carbamates,
pubmed-meshheading:10476732-Child,
pubmed-meshheading:10476732-Child, Preschool,
pubmed-meshheading:10476732-Echinococcosis,
pubmed-meshheading:10476732-Echinococcosis, Hepatic,
pubmed-meshheading:10476732-Echinococcosis, Pulmonary,
pubmed-meshheading:10476732-Echinococcus,
pubmed-meshheading:10476732-Evaluation Studies as Topic,
pubmed-meshheading:10476732-Female,
pubmed-meshheading:10476732-Follow-Up Studies,
pubmed-meshheading:10476732-Humans,
pubmed-meshheading:10476732-Male,
pubmed-meshheading:10476732-Mebendazole,
pubmed-meshheading:10476732-Middle Aged,
pubmed-meshheading:10476732-Time Factors
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pubmed:year |
1999
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|
pubmed:articleTitle |
Long-term evaluation of patients with hydatidosis treated with benzimidazole carbamates.
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pubmed:affiliation |
Department of Infectious and Tropical Diseases, University of Rome La Sapienza, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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