Linked Life Data

10476054

Source:http://linkedlifedata.com/resource/pubmed/id/10476054

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1999-10-12
pubmed:abstractText
Cebus apella is an acceptable model for chronic chagasic cardiomyopathy (CCC), since it is possible to experimentally induce cardiac lesions after 1 year of Trypanosoma cruzi infection. The T. cruzi Y strain, shown previously to produce CCC in C. apella monkeys, was used to experimentally infect 10 monkeys. Parasitological, serological and clinical parameters were monitored during a 19-month follow-up, and systemic cytokine responses were assessed sequentially in five monkeys selected according to the differential parasitemia pattern exhibited. Ten additional monkeys, infected with the same strain for 5, 10 and 12 years, were analysed cross-sectionally. Three monkeys/time point and one uninfected control animal were sacrificed for gross pathology, histology, presence of parasites, and local cytokine gene expression. Elevated expression of interleukin (IL)-4 was observed throughout the study in monkeys that had persistent, high parasitemias, whereas a high level of interferon (IFN)-gamma was seen in monkeys that controlled parasitemias soon after infection. Chronically infected monkeys expressed a nonpolarized, Th0-type response. Cardiac tissue collected from a monkey that succumbed to acute infection had elevated levels of proinflammatory cytokine [IL-1beta, IL-6, tumour necrosis factor-alpha] and interstitial cell adhesion molecule (ICAM)-1, platelet-derived growth factor (PDGF)-alpha, transforming growth factor (TGF)-beta and IL-10 transcripts. Cytokine production in cardiac tissue of chronically infected monkeys was also characterized by elevated expression of ICAM-1, PDGF-alpha and TGF-beta, which correlated with the detection of T. cruzi DNA by polymerase chain reaction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0141-9838
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
451-60
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:10476054-Acute Disease, pubmed-meshheading:10476054-Animals, pubmed-meshheading:10476054-Cebus, pubmed-meshheading:10476054-Chagas Cardiomyopathy, pubmed-meshheading:10476054-Chronic Disease, pubmed-meshheading:10476054-Cytokines, pubmed-meshheading:10476054-Disease Models, Animal, pubmed-meshheading:10476054-Electrocardiography, pubmed-meshheading:10476054-Female, pubmed-meshheading:10476054-Intercellular Adhesion Molecule-1, pubmed-meshheading:10476054-Interferon-gamma, pubmed-meshheading:10476054-Interleukins, pubmed-meshheading:10476054-Male, pubmed-meshheading:10476054-Myocardium, pubmed-meshheading:10476054-Platelet-Derived Growth Factor, pubmed-meshheading:10476054-RNA, Messenger, pubmed-meshheading:10476054-Time Factors, pubmed-meshheading:10476054-Transforming Growth Factor beta, pubmed-meshheading:10476054-Trypanosoma cruzi, pubmed-meshheading:10476054-Tumor Necrosis Factor-alpha
pubmed:year
1999
pubmed:articleTitle
Local and systemic cytokine expression during experimental chronic Trypanosoma cruzi infection in a Cebus monkey model.
pubmed:affiliation
Instituto de Investigaciones en Ciencias de la Salud, Asuncion, Paraguay.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't