Linked Life Data

10474652

Source:http://linkedlifedata.com/resource/pubmed/id/10474652

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-9-15
pubmed:abstractText
We have measured the flow conductivity, kappa/eta, of discs of rat dermis with and without digestion with hyaluronidase. We found no significant difference between the flow conductivity of hyaluronan digested (kappa/eta = 5.56 +/- 2.74 cm4/dyne.s (n = 13)) and untreated tissue (kappa/eta = 6.03 +/- 3.15 cm4/dyne.s (n = 13)). For the first time in such experiments the overall tissue hyaluronan content as well as the difference in concentration of this material across tissues subjected to conditions of flow was measured. Similarly, the overall hydration and the difference in fluid content across the tissue is also reported. We have demonstrated that approximately 99% of the tissue hyaluronan was digested as a result of activity of the enzyme. No difference in hyaluronan across the tissue was found in the flow experiments (i.e., with or without digestion). We found significant change in the overall tissue hydration for controls and for either of the two types of flow experiments performed. Likewise, we found significant hydration differences across the tissues under both types of flow conditions. A trend in decreasing hydration associated with digestion of hyaluronan in the flow experiments was found.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0006-355X
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Hyaluronan, hydration and flow conductivity of rat dermis.
pubmed:affiliation
Department of Chemical Engineering, University of British Columbia, Vancouver, Canada. bert@chml.ubc.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't