Source:http://linkedlifedata.com/resource/pubmed/id/10471528
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1999-10-20
|
| pubmed:abstractText |
In view of recent knowledge on proteins regulating the cell cycle, we re-evaluated proliferative features of 98 diffusely growing non-Hodgkin's lymphomas. The combined use of 5 proliferation-associated variables (mitotic indices and percentages of Ki-67(+), p34(cdc2+), cyclin A(+) and cyclin B(+) cells) and their entry into a multivariate cluster analysis separated, without overlaps, the entire cohort into 3 groups (clusters) with (1) low, (2) intermediate and (3) high proliferative activity. Conversely, bivariate plots exposed considerable cluster overlaps. Multivariate stepwise discriminant analysis of all cases revealed a decreasing order of discriminant power for % Ki-67(+) cells > % p34(cdc2+) cells > mitotic index > % cyclin A(+) cells > % cyclin B(+) cells. The combined use of 2 variables only, mitotic index and % p34(cdc2+) cells, allowed a clear-cut separation of clusters 2 and 3. In bivariate plots, correlations were best between % Ki-67(+) cells and % cyclin A(+) cells and between mitotic indices and % cyclin B(+) cells. Except for chronic lymphocytic leukemias, immunocytomas and marginal zone lymphomas (all in cluster 1), individual lymphoma entities were distributed among at least 2 clusters. There was, however, a marked preponderance of mantle cell lymphomas and diffuse follicular center lymphomas in cluster 1 and of diffuse large B-cell lymphomas and peripheral T-cell lymphomas in cluster 2. Anaplastic large-cell lymphomas predominated in cluster 3 and responded best to therapy.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
|
| pubmed:issn |
0020-7136
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| pubmed:author |
pubmed-author:BarbiniPP,
pubmed-author:BellasFF,
pubmed-author:CeveniniGG,
pubmed-author:CostePP,
pubmed-author:CottierHH,
pubmed-author:GiordanoAA,
pubmed-author:KraftRR,
pubmed-author:LaissueJ AJA,
pubmed-author:LazziSS,
pubmed-author:LeonciniLL,
pubmed-author:LuziPP,
pubmed-author:MeghaTT,
pubmed-author:PileriSS,
pubmed-author:TosiPP
|
| pubmed:copyrightInfo |
Copyright 1999 Wiley-Liss, Inc.
|
| pubmed:issnType |
Print
|
| pubmed:day |
8
|
| pubmed:volume |
83
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
203-9
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:10471528-Adolescent,
pubmed-meshheading:10471528-Adult,
pubmed-meshheading:10471528-Aged,
pubmed-meshheading:10471528-Aged, 80 and over,
pubmed-meshheading:10471528-CDC2 Protein Kinase,
pubmed-meshheading:10471528-Cell Division,
pubmed-meshheading:10471528-Child,
pubmed-meshheading:10471528-Cluster Analysis,
pubmed-meshheading:10471528-Cohort Studies,
pubmed-meshheading:10471528-Cyclin A,
pubmed-meshheading:10471528-Cyclin B,
pubmed-meshheading:10471528-Discriminant Analysis,
pubmed-meshheading:10471528-Female,
pubmed-meshheading:10471528-Humans,
pubmed-meshheading:10471528-Lymphoma, Non-Hodgkin,
pubmed-meshheading:10471528-Male,
pubmed-meshheading:10471528-Middle Aged,
pubmed-meshheading:10471528-Multivariate Analysis,
pubmed-meshheading:10471528-Retrospective Studies
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Expression of p34(cdc2) and cyclins A and B compared to other proliferative features of non-Hodgkin's lymphomas: a multivariate cluster analysis.
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| pubmed:affiliation |
Institute of Pathology, University of Sassari, Sassari, Italy. leoncinil@unisi.it
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|