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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1999-10-8
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pubmed:abstractText |
Recent clinical observations question that the antidepressant effect of fluoxetine (Prozac) can be explained solely with serotonin reuptake inhibition in the central nervous system. We hypothesized that fluoxetine affects the tone of vessels and thereby modulates cerebral blood flow.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0039-2499
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1949-54
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10471449-3-Pyridinecarboxylic acid...,
pubmed-meshheading:10471449-Animals,
pubmed-meshheading:10471449-Calcium Channel Agonists,
pubmed-meshheading:10471449-Cerebral Arteries,
pubmed-meshheading:10471449-Dose-Response Relationship, Drug,
pubmed-meshheading:10471449-Endothelium, Vascular,
pubmed-meshheading:10471449-Fluoxetine,
pubmed-meshheading:10471449-Male,
pubmed-meshheading:10471449-Norepinephrine,
pubmed-meshheading:10471449-Potassium Channels,
pubmed-meshheading:10471449-Rats,
pubmed-meshheading:10471449-Rats, Wistar,
pubmed-meshheading:10471449-Serotonin,
pubmed-meshheading:10471449-Serotonin Uptake Inhibitors,
pubmed-meshheading:10471449-Vasoconstriction,
pubmed-meshheading:10471449-Vasoconstrictor Agents,
pubmed-meshheading:10471449-Vasodilation
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pubmed:year |
1999
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pubmed:articleTitle |
Fluoxetine dilates isolated small cerebral arteries of rats and attenuates constrictions to serotonin, norepinephrine, and a voltage-dependent Ca(2+) channel opener.
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pubmed:affiliation |
Institutes of Pathophysiology and Pharmacology, Semmelweis University of Medicine, PO Box 370, H-1445 Budapest, Hungary.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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