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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1999-10-8
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pubmed:abstractText |
Protease-activated receptor-2 (PAR-2) can be activated after proteolysis of the amino terminal of the receptor by trypsin or by synthetic peptides with a sequence corresponding to the endogenous tethered ligand exposed by trypsin (eg, SLIGRL-NH(2)). PAR-2 mediates nitric oxide (NO)-dependent dilatation in cerebral arteries, but it is unknown whether PAR-2 function is altered in cardiovascular diseases. Since hypertension selectively impairs NO-mediated cerebral vasodilatation in response to acetylcholine and bradykinin, we sought to determine whether PAR-2-mediated vasodilatation is similarly adversely affected by this disease state.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroarginine,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroprusside,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, PAR-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, PAR-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thrombin,
http://linkedlifedata.com/resource/pubmed/chemical/seryl-leucyl-isoleucyl-glycyl--argin...,
http://linkedlifedata.com/resource/pubmed/chemical/thrombin receptor peptide (42-47)
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0039-2499
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1933-40; discussion 1941
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10471447-Acetylcholine,
pubmed-meshheading:10471447-Animals,
pubmed-meshheading:10471447-Cerebral Arteries,
pubmed-meshheading:10471447-Chronic Disease,
pubmed-meshheading:10471447-Enzyme Inhibitors,
pubmed-meshheading:10471447-Hypertension,
pubmed-meshheading:10471447-Male,
pubmed-meshheading:10471447-Nitroarginine,
pubmed-meshheading:10471447-Nitroprusside,
pubmed-meshheading:10471447-Oligopeptides,
pubmed-meshheading:10471447-Peptide Fragments,
pubmed-meshheading:10471447-Rats,
pubmed-meshheading:10471447-Rats, Inbred SHR,
pubmed-meshheading:10471447-Rats, Inbred WKY,
pubmed-meshheading:10471447-Receptor, PAR-1,
pubmed-meshheading:10471447-Receptor, PAR-2,
pubmed-meshheading:10471447-Receptors, Thrombin,
pubmed-meshheading:10471447-Vasodilation
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pubmed:year |
1999
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pubmed:articleTitle |
Evidence for selective effects of chronic hypertension on cerebral artery vasodilatation to protease-activated receptor-2 activation.
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pubmed:affiliation |
Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia. c.sobey@pharmacology.unimelb.edu.au
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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