| pubmed-article:10471124 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10471124 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10471124 | lifeskim:mentions | umls-concept:C0229664 | lld:lifeskim |
| pubmed-article:10471124 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:10471124 | lifeskim:mentions | umls-concept:C1155046 | lld:lifeskim |
| pubmed-article:10471124 | lifeskim:mentions | umls-concept:C0015690 | lld:lifeskim |
| pubmed-article:10471124 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10471124 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10471124 | pubmed:issue | 5-6 | lld:pubmed |
| pubmed-article:10471124 | pubmed:dateCreated | 2000-1-24 | lld:pubmed |
| pubmed-article:10471124 | pubmed:abstractText | Oils enriched in certain polyunsaturated fatty acids suppress joint pain and swelling in rheumatoid arthritis patients with active synovitis. Because T lymphocyte activation is important for propagation of joint tissue injury in patients with rheumatoid arthritis, we examined the effects of fatty acids added in vitro on proliferation of human T lymphocytes stimulated with monoclonal antibodies to CD3 and CD4. Unsaturated fatty acids reduced T cell proliferation in a dose dependent manner (dihomogammalinolenic acid > gammalinolenic acid > eicosapentaenoic acid > arachidonic acid). Removal of fatty acids from cultures before cell stimulation did not change the effects, but addition of fatty acids after cell stimulation failed to reduce T cell responses. The saturated palmitic acid did not influence T cell growth. These studies indicate that small changes in cellular fatty acids can have profound effects on early events in T cell signaling and on T cell function. | lld:pubmed |
| pubmed-article:10471124 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471124 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10471124 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471124 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10471124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471124 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10471124 | pubmed:issn | 0952-3278 | lld:pubmed |
| pubmed-article:10471124 | pubmed:author | pubmed-author:ZurierR BRB | lld:pubmed |
| pubmed-article:10471124 | pubmed:author | pubmed-author:LaposataMM | lld:pubmed |
| pubmed-article:10471124 | pubmed:author | pubmed-author:RossettiR GRG | lld:pubmed |
| pubmed-article:10471124 | pubmed:author | pubmed-author:SeilerC MCM | lld:pubmed |
| pubmed-article:10471124 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10471124 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:10471124 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10471124 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10471124 | pubmed:pagination | 371-5 | lld:pubmed |
| pubmed-article:10471124 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10471124 | pubmed:meshHeading | pubmed-meshheading:10471124... | lld:pubmed |
| pubmed-article:10471124 | pubmed:meshHeading | pubmed-meshheading:10471124... | lld:pubmed |
| pubmed-article:10471124 | pubmed:meshHeading | pubmed-meshheading:10471124... | lld:pubmed |
| pubmed-article:10471124 | pubmed:meshHeading | pubmed-meshheading:10471124... | lld:pubmed |
| pubmed-article:10471124 | pubmed:meshHeading | pubmed-meshheading:10471124... | lld:pubmed |
| pubmed-article:10471124 | pubmed:meshHeading | pubmed-meshheading:10471124... | lld:pubmed |
| pubmed-article:10471124 | pubmed:meshHeading | pubmed-meshheading:10471124... | lld:pubmed |
| pubmed-article:10471124 | pubmed:meshHeading | pubmed-meshheading:10471124... | lld:pubmed |
| pubmed-article:10471124 | pubmed:meshHeading | pubmed-meshheading:10471124... | lld:pubmed |
| pubmed-article:10471124 | pubmed:meshHeading | pubmed-meshheading:10471124... | lld:pubmed |
| pubmed-article:10471124 | pubmed:meshHeading | pubmed-meshheading:10471124... | lld:pubmed |
| pubmed-article:10471124 | pubmed:articleTitle | Human peripheral blood T lymphocyte proliferation after activation of the T cell receptor: effects of unsaturated fatty acids. | lld:pubmed |
| pubmed-article:10471124 | pubmed:affiliation | Division of Rheumatology, University of Massachusetts Medical Center, Worcester 01655-0335, USA. | lld:pubmed |
| pubmed-article:10471124 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10471124 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10471124 | lld:pubmed |
